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Article
Open AccessSOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells
Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHO...
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Article
WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function
The Hedgehog-GLI (HH-GLI) signaling plays a critical role in controlling growth and tissue patterning during embryogenesis and is implicated in a variety of human malignancies, including those of the skin. Pho...