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Article
Nanomedicine approaches for medulloblastoma therapy
Over the past 30 years, brain tumors have been intensively studied with a variety of therapeutic approaches. However, brain cancer is still one of the most lethal forms of cancer, and the mortality rates have ...
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Article
Development of a pH-Responsive Polymer Based on Hyaluronic Acid Conjugated with Imidazole and Dodecylamine for Nanomedicine Delivery
Hyaluronic acid (HA) is being actively studied as a drug carrier due to its favorable properties and functional groups for chemical modification. Despite its high functionality, pKa of HA (3–4, carboxyl groups) i...
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Article
Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability
Lutein has been used as a dietary supplement for the treatment of eye diseases, especially age-related macular degeneration. For oral formulations, we investigated lutein stability in artificial set-ups mimick...
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Article
Hyperthermal paclitaxel-bound albumin nanoparticles co-loaded with indocyanine green and hyaluronidase for treating pancreatic cancers
Albumin nanoparticles have become an attractive cancer nanomedicine platform due to their pharmaceutical advantages. Recently, photothermal therapy has been extensively applied to cancer treatment due to heat-...
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Article
Preparation of Gastro-retentive Tablets Employing Controlled Superporous Networks for Improved Drug Bioavailability
The development of an oral formulation that ensures increased bioavailability of drugs is a great challenge for pharmaceutical scientists. Among many oral formulation systems, a drug delivery system employing ...
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Article
Principles and applications of nanomaterial-based hyperthermia in cancer therapy
Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and...
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Article
A pH-Sensitive Polymer for Cancer Targeting Prepared by One-Step Modulation of Functional Side Groups
Nanocarriers with pH-sensitive functionality are of great interest in the development of pH-dependent drug release compounds in acidic tumor microenvironments. A new polyelectrolyte block copolymer, poly[(benzyl-
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Article
Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications
The development of novel drug delivery systems based on well-defined polymer therapeutics has led to significant improvements in the treatment of multiple disorders. Advances in material chemistry, nanotechnol...
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Chapter and Conference Paper
Development of New Tri-block Copolymers for Pharmaceutical Applications
We have developed several tri-block copolymers for nanomedicines. First, a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) was synthesize...
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Article
Recent advance of pH-sensitive nanocarriers targeting solid tumors
pH sensitive nanocarriers have showed the tumor targeted drug delivery and release by enhanced permeability and retention effect and responsiveness of acidic pH conditions of the solid tumors. The protonation ...
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Article
Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications
Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethy...
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Article
Triblock copolymers for nano-sized drug delivery systems
Triblock copolymers have been widely used as a material for develo** drug delivery systems (DDS). In terms of architecture, triblock copolymers could be classified into symmetric and asymmetric triblock cop...
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Article
Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles
In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon ...
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Article
Nanomedicines for oral administration based on diverse nanoplatform
Nanotechnology has been applied to the oral drug delivery for enhancing bioavailability after oral administration. Numerous forms of reported nanomedicines are classified as lipid based nanomedicine (LBNM), po...
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Article
Functional poly(l-lysine) derivative nanogels with acidic pH-pulsed antitumor drug release properties
We developed novel poly(l-lysine) [poly(Lys)] derivative nanogels with smart drug release properties. Poly(Lys) derivative was prepared after the chemical reaction of poly(Lys) and 3-diethylaminopropyl isothiocya...
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Article
Development of tiotropium inhalation formulations for the treatment of chronic obstructive pulmonary disease
Tiotropium, a longer acting anticholinergic bronchodilator, has been widely used for treatment of chronic obstructive pulmonary disease (COPD). To improve the therapeutic effect of tiotropium, we developed var...
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Article
Preparation of chlorine e6-conjugated single-wall carbon nanotube for photodynamic therapy
We fabricated single-wall carbon nanotubes (SWNTs) modified with chlorine e6 (as a photosensitizing drug: Ce6) and poly(ethylene glycol) (PEG, as a polymeric stabilizer) were fabricated to develop a light-sens...
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Article
Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes
To study the development of porous poly(lactic-co-glycolic acid) microparticles (PLGA MPs) coated initially with albumin and then with palmityl-acylated exendin-4 (Pal-Ex4) as an inhalation system for treating...
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Article
Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems
pH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs specifically to solid tumors or to acidosis-affected rheumatic joints. In this study, a poly(L-aspartic acid-graftim...
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Article
Preparation of multifunctional polymeric micelles for antiviral treatment
In this study, a poly(L-lactic acid)-b-poly(ethylene glycol) (PLLA-b-PEG) diblock copolymer modified with a sialic acid derivative (methyl-b-neuraminic acid: mNA) was prepared for the development and application ...
