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Article
Open AccessPreclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway
Reprogramming of the serine synthesis pathway (SSP) is intricately linked to the progression of epithelial ovarian cancer (EOC). CBR-5884, a selective small-molecule inhibitor targeting phosphoglycerate dehydr...
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Article
Open AccessZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis
Zinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer (EOC) remains unknown. In this study, we aimed to investigate the clin...
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Article
Impact of 810nm diode laser, intraoral and extraoral applications, on postoperative pain, swelling, wound healing, and patient satisfaction following mandibular third molar extraction: a comparative study
This study aimed to evaluate the effects of an 810 nm diode laser, intraoral and extraoral, on postoperative pain, swelling, wound healing, and patient satisfaction after mandibular third molar extraction.
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Article
The 980-nm diode laser treatment for oral venous lakes: report of a series of 11 cases
The objective of this study was to evaluate the effectiveness of 980-nm diode laser treatment on oral venous lakes (OVLs).
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Article
Doublecortin-like kinase 2 promotes breast cancer cell invasion and metastasis
Doublecortin-like kinase 2 (DCLK2) is a microtubule-associated protein kinase that participates in neural development and maturation; however, whether it is involved in tumour progression remains unclear.
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Article
Multi-objective optimisation of cutting parameters for drilling-induced damages and thrust force in AFRP drilling
Aramid fibre-reinforced polymer (AFRP) composites have been widely used in the aerospace, defence, and construction industries. However, due to the high toughness and multiphase structure, AFRP is prone to sev...
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Article
Open AccessPlasma C4 level was associated with mortality, cardiovascular and cerebrovascular complications in hemodialysis patients
Patients on maintenance hemodialysis (HD) exhibit a high risk of death, cardiovascular and cerebrovascular diseases (CCDs). Previous studies indicated complement activation associated with the increased risk o...
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Article
Open AccessPten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice
Serotonin (5-HT)-based antidepressants, selective serotonin reuptake inhibitors (SSRIs) aim to enhance serotonergic activity by blocking its reuptake. We propose PTEN as a target for an alternative approach fo...
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Article
Open AccessAutosomal dominant tubulointerstitial kidney disease genotype and phenotype correlation in a Chinese cohort
Genes of UMOD, HNF1B, MUC1, REN and SEC61A1 were reported to be associated with autosomal dominant tubulointerstitial kidney disease (ADTKD). 48 probands and their family members (N = 27) were enrolled in this ge...
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Article
Diagnostic value of mitral regurgitant jet volume in the assessment of mitral regurgitation severity by general imaging three-dimensional quantification
Accurate quantification of mitral regurgitation (MR) severity is critical for appropriate clinical decision making regarding surgical intervention. General imaging three-dimensional quantification (GI3DQ) meth...
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Article
Tumor-associated macrophage infiltration and prognosis in colorectal cancer: systematic review and meta-analysis
Tumor-associated macrophages (TAMs) are key components of colorectal cancer (CRC) microenvironment, but their role in CRC prognosis is not fully defined.
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Article
Open AccessThe impact of different geometric assumption of mitral annulus on the assessment of mitral regurgitation volume by Doppler method
Mitral regurgitation volume (MRvol) by quantitative pulsed Doppler (QPD) method previously recommended suffers from geometric assumption error because of circular geometric assumption of mitral annulus (MA). T...
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Article
Open AccessEnhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
BET bromodomain inhibitors (BETi), such as JQ1, have been demonstrated to effectively kill multiple types of cancer cells. However, the underlying mechanisms for BETi resistance remain largely unknown. Our evi...
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Article
Plasma Complement Protein C3a Level Was Associated with Abdominal Aortic Calcification in Patients on Hemodialysis
The complement system plays an important role in cardiovascular disease in patients on hemodialysis. Vascular calcification is also one of the major causes of cardiovascular disease. We want to investigate the...
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Article
Open AccessAssessment of right atrium dysfunction in patients with obstructive sleep apnea syndrome using velocity vector imaging
This study aimed to assess the changes of RA function in patients with obstructive sleep apnea syndrome (OSAS) using velocity vector imaging (VVI) and to evaluate the application of VVI technology.
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Article
Open AccessMicroRNA profiling of diabetic atherosclerosis in a rat model
The incidence of diabetic atherosclerosis (DA) is increasing worldwide. The study aim was to identify differentially expressed microRNAs (DE-miRs) potentially associated with the initiation and/or progression ...
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Article
Open AccessQuantitative evaluation of longitudinal strain in layer-specific myocardium during normal pregnancy in China
The myocardial wall of the left ventricle is a complex, multilayered structure and is not homogenous. The aim of this study was to determine longitudinal strain (LS) in the three myocardial layers in normal pr...
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Article
Open AccessWhole genome sequence and comparative genomic analysis of multidrug-resistant Staphylococcus capitis subsp. urealyticus strain LNZR-1
Staphylococcus capitis is an emerging opportunistic pathogen of humans, and found as a colonizer of the human gut. Here, we report a case of S. capitis subsp. urealyticus infection. The strain LNZR-1 was isolated...
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Article
Equitable total coloring of F n ⋁ W n
The minimum number of total independent partition sets of V ∪ E of graph G(V,E) is called the total chromatic number of G denoted by χ t (G). If the diff...
