176 Result(s)

Article

An ‘activator-repressor’ loop controls the anthocyanin biosynthesis in red-skinned pear

The color of red-skinned pear (Pyrus spp.) is primarily attributed to accumulation of anthocyanins, which provide nutritional benefits for human health and are closely associated with the commercial value of frui...

Guangyan Yang, Zhaolong Xue, Kui Lin-Wang, Guosong Chen… in Molecular Horticulture (2024)

Article

Author Correction: A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2024)

Article

METTL3-mediated deficiency of lncRNA HAR1A drives non-small cell lung cancer growth and metastasis by promoting ANXA2 stabilization

We previously reported lncRNA HAR1A as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the delicate working mechanisms of this lncRNA remain obscure. Herein, we demonstrated that the ectopic ex...

**aodong Ling, Cuicui Qi, Kui Cao, Mengdi Lu, Yingnan Yang… in Cell Death Discovery (2024)

Article

PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically describ...

Liang Chen, Haotong Li, **aorui Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer

Yuwei Pu, **rong Wei, Yong Wu, Kui Zhao, Yongyou Wu… in Cell Biochemistry and Biophysics (2024)

Article

Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases

Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option that has attracted much attention due to its low immunogenic...

Limin Liu, Yulin Ye, Rui Lin, Tianyu Liu, Sinan Wang… in Cell Communication and Signaling (2024)

Article

RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer

The aim of this study was to explore the associations of RIPK1 polymorphisms, plasma levels and mRNA expression with susceptibility to epithelial ovarian cancer (EOC) and clinical outcome.

Xuedong Wang, Kui Deng, **g Tao, Juan Zou, Yiting Du, Li Dai in Cancer Cell International (2023)

Article

A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2023)

Article

Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neu...

Ashok Iyaswamy, Abhimanyu Thakur, **n-Jie Guan… in Signal Transduction and Targeted Therapy (2023)

Article

Immune landscape and redox imbalance during neurological disorders in COVID-19

The outbreak of Coronavirus Disease 2019 (COVID-19) has prompted the scientific community to explore potential treatments or vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the v...

Abhimanyu Thakur, Vartika Sharma, Sera Averbek, Lifan Liang… in Cell Death & Disease (2023)

Article

Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscur...

Zongyong Ai, Baohua Niu, Yu Yin, Lifeng **ang, Gaohui Shi, Kui Duan… in Cell Research (2023)

Article

VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However, how IRS-1 targets the intr...

**u Kui Gao, Zu Kang Sheng, Ye Hong Lu, Yu Ting Sun, ** Sheng Rao… in Cell Discovery (2023)

Article

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...

Yan He, Can-Can Zheng, **g Yang, Shu-Jun Li, Tao-Yang Xu, **an Wei… in Cell Discovery (2023)

Article

Correction: Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders

Haiyu Li, Yongyao Tang, Yu**g Wang, Yue Li, Yi Yang, Kui Liao… in Cell Death & Disease (2023)

Article

Dose-specific efficacy of adipose-derived mesenchymal stem cells in septic mice

Mesenchymal stem cells (MSCs) therapy for sepsis has been extensively studied in the past decade; however, the treatment regimen and mechanism of action of MSCs remain elusive. Here, we attempted to understand...

Kui Li, Tao Wang, Rui Li, Fulai Xue, Guodan Zeng… in Stem Cell Research & Therapy (2023)

Article

MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

Unhealable diabetic wounds need to be addressed with the help of newer, more efficacious strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new h...

Qiankun Li, Wenzhi Hu, Qilin Huang, Jie Yang… in Signal Transduction and Targeted Therapy (2023)