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High-fidelity endonuclease variant HypaCas9 facilitates accurate allele-specific gene modification in mouse zygotes

CRISPR/Cas9 has been widely used for the efficient generation of genetically modified animals; however, this system could have unexpected off-target effects. In the present study, we confirmed the validity of ...

Arisa Ikeda, Wataru Fujii, Koji Sugiura, Kunihiko Naito in Communications Biology (2019)