4 Result(s)
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Article
Open AccessRNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer
Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC lesions and are responsib...
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Article
Open AccessDecreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments
Breast cancer (BC) is the most common cancer occurring in women but also rarely develops in men. Recent advances in early diagnosis and development of targeted therapies have greatly improved the survival rate...
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Article
Open AccessThe histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis
The HER2-positive breast cancer subtype (HER2+-BC) displays a particularly aggressive behavior. Anti-HER2 therapies have significantly improved the survival of patients with HER2+-BC. However, a large number of p...
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Article
The Interrelating Dynamics of Hypoxic Tumor Microenvironments and Cancer Cell Phenotypes in Cancer Metastasis
The interrelating dynamics of the primary tumor cells and their surrounding microenvironment might determine phenotypic characteristics of disseminated tumor cells and contribute to cancer metastasis. Cytoprot...
