9 Result(s)

Article

Relationship of Ki-67 index in biopsies of metastatic breast cancer tissue and circulating tumor cells (CTCs) at the time of biopsy collection

The proliferation marker Ki-67 is a major pathological feature for the description of the state of disease in breast cancer. It helps to define the molecular subtype and to stratify between therapy regimens in...

Thomas M. Deutsch, Chiara Fischer, Fabian Riedel… in Archives of Gynecology and Obstetrics (2024)

Article

Circulating tumour cells for early detection of clinically relevant cancer

Given that cancer mortality is usually a result of late diagnosis, efforts in the field of early detection are paramount to reducing cancer-related deaths and improving patient outcomes. Increasing evidence in...

Rachel Lawrence, Melissa Watters, Caitlin R. Davies… in Nature Reviews Clinical Oncology (2023)

Article

A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflam...

Liv Cecilie Vestrheim Thomsen, Alfred Honoré… in Cancer Immunology, Immunotherapy (2023)

Article

Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma

Advanced cutaneous squamous cell carcinoma (cSCC) encompasses unresectable and metastatic disease. Although immune checkpoint inhibition has been approved for this entity recently, a considerable proportion of...

Glenn Geidel, Isabel Heidrich, Julian Kött, Stefan W. Schneider… in npj Precision Oncology (2022)

Article

Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions

Bone metastasis remains a major cause of mortality and morbidity in breast cancer. Therefore, there is an urgent need to better select high-risk patients in order to adapt patient’s treatment and prevent bone ...

Francesco Pantano, Martine Croset, Keltouma Driouch, Natalia Bednarz-Knoll… in Oncogene (2021)

Article

HER2-targeted therapy influences CTC status in metastatic breast cancer

As an independent, negative-prognostic biomarker for progression-free survival (PFS) and overall survival (OS), circulating tumor cells (CTCs) constitute a promising component for develo** a liquid biopsy fo...

Thomas M. Deutsch, Sabine Riethdorf, Carlo Fremd… in Breast Cancer Research and Treatment (2020)

Article

Rationale and Design of the Hamburg City Health Study

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk an...

Annika Jagodzinski, Christoffer Johansen… in European Journal of Epidemiology (2020)

Article

Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial

The focus of this study is to identify particular microRNA (miRNA) signatures in exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2)-positive and triple-negative (TN) subtypes o...

Ines Stevic, Volkmar Müller, Karsten Weber, Peter A. Fasching, Thomas Karn… in BMC Medicine (2018)

Article

Erratum to: Current role of liquid biopsy in metastatic breast cancer and future perspectives

Arkadius Polasik, Thomas W. P. Friedl, Amelie Schramm, Fabienne Schochter… in Der Gynäkologe (2016)