73 Result(s)
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Article
Introductory Overview
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Article
Biological Characteristics of Micrometastatic Cancer Cells in Bone Marrow
There is emerging evidence that epithelial tumor cells are able to disseminate to secondary organs at an early stage of primary tumor development. One of the most prominent secondary organs screened for this t...
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Reference Work Entry In depth
Micrometastasis
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Article
Dissecting the metastatic cascade
In some solid tumours, such as those of the head and neck, the presence of lymph-node metastases is closely linked to the development of distant metastases. In...
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Article
Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives
Early tumor cell dissemination at the single-cell level can be revealed in patients with breast cancer by using sensitive immunocytochemical and molecular assays. Recent clinical studies involving more than 40...
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Article
Molecular mechanisms of metastasis
A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we...
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Article
Recent translational research: circulating tumor cells in breast cancer patients
In breast cancer patients, hematogenous tumor cell dissemination can be detected, even at the single cell level, by applying immunocytochemical and molecular assays. Various methods for the detection of circul...
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Article
Open AccessA critical evaluation of loss of heterozygosity detected in tumor tissues, blood serum and bone marrow plasma from patients with breast cancer
The aim of the study was to perform a comparative analysis of LOH (loss of heterozygosity) in primary tumors as well as peripheral blood and bone marrow (BM) of patients with breast cancer (BCa).
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Chapter
Prostate Cancer: Detection of Free Tumor-Specific DNA in Blood and Bone Marrow
Prostate carcinoma is one of the most frequently diagnosed cancer types in men. If diagnosed at an early stage, prostate cancer is usually treatable. For a patient with a clinically localized tumor, the primar...
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Article
Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
Immunocytochemical or molecular assays allow the detection of single disseminated tumor cells (DTCs) in the bone marrow (BM) or the peripheral blood in 10% to 60% of breast cancer patients without signs of met...
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Article
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Tumour cell dissemination is an early event in tumorigenesis and is relevant for metastatic progression (in particular for breast cancer). These data have led ...
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Reference Work Entry In depth
Micrometastasis
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Article
Open AccessFull-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer
We evaluated whether CK19, one of the main cytoskeleton proteins of epithelial cells, is released as full-length protein from viable tumor cells and whether this property is relevant for metastatic progression...
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Article
Open AccessComparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
The origin and clinical relevance of circulating cell-free tumor DNA in the blood of cancer patients is still unclear. Here we investigated whether the detection of this DNA is related to bone marrow (BM) micr...
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Article
Clinical relevance and current challenges of research on disseminating tumor cells in cancer patients
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Article
Open AccessPromoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by Methyl-CpG binding proteins and histone modifications
The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts ...
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Article
What's new on circulating tumor cells? A meeting report
Circulating tumor cells (CTCs) provide unique information for the management of cancer patients. The 7th International Symposium on Minimal Residual Cancer has focused on state of the art research, including e...
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Article
Open AccessCirculating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
MicroRNAs (miRs) are interesting new diagnostic targets that may provide important insights into the molecular pathogenesis of breast cancer. Here we evaluated, for the first time, the feasibility and clinical...
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Reference Work Entry In depth
Micrometastasis
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Chapter and Conference Paper
Increase in Circulating MicroRNA Levels in Blood of Ovarian Cancer Patients
Since their functional role in tumour biology is to a large extent unknown, the focus of the current study is the extraction and quantification of circulating microRNAs. Using serum of patients with ovarian ca...
