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The measurement of CSF flow through the aqueduct in normal and hydrocephalic children: from where does it come, to where does it go?

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    Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

    Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2′-O-hexadecy...

    Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas in Nature Biotechnology (2022)