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  1. Article

    Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

    Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2′-O-hexadecy...

    Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas in Nature Biotechnology (2022)