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  1. No Access

    Article

    Malaria is a cause of iron deficiency in African children

    Malaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID1. To test th...

    John Muthii Muriuki, Alexander J. Mentzer, Ruth Mitchell, Emily L. Webb… in Nature Medicine (2021)

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    Article

    A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility

    The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria...

    Mahamadou Diakite, Taane G. Clark, Sarah Auburn, Susana Campino… in Human Genetics (2009)

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    Article

    Association of the GNAS locus with severe malaria

    Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria parasite at a cellular level. Obstruction of signal transduction via the erythroc...

    Sarah Auburn, Mahamadou Diakite, Andrew E. Fry, Anita Ghansah… in Human Genetics (2008)

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    Article

    Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever

    Massive release of tumor necrosis factor is responsible for the potentially fatal Jarisch-Herxheimer reaction that follows antibiotic treatment of relapsing fever due to Borrelia...

    Vincent Vidal, Ian G. Scragg, Sally J. Cutler, Kirk A. Rockett… in Nature Medicine (1998)