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Article
Genomic analysis of local variation and recent evolution in Plasmodium vivax
Dominic Kwiatkowski and colleagues report a population genomic analysis of 228 clinical samples of Plasmodium vivax from 13 countries, with an emphasis on Southeast Asia. They analyze patterns of genetic structur...
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Article
Open AccessGenetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya
The relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and clinical phenomena such as primaquine-sensitivity and protection from severe malaria remains poorly defined, with past associati...
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Article
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Dominic Kwiatkowski and colleagues report analysis of genetic variation in 826 Plasmodium falciparum samples collected from 10 locations in West Africa and southeast Asia. They characterize the population structu...
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Article
Open AccessLarge-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
The TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA SNPs with T2D but the majority have been small-scale and produced no convincing evidence of asso...
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Article
Genome-wide and fine-resolution association analysis of malaria in West Africa
Dominic Kwiatkowski and colleagues of the MalariaGEN and the WTCCC consortiums report a genome-wide analysis of severe malaria in The Gambia. They provide guidance for design of GWAS in African populations, an...
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Article
A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility
The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria...
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Article
Association of the GNAS locus with severe malaria
Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria parasite at a cellular level. Obstruction of signal transduction via the erythroc...
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Article
In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading
In vivo characterization of regulatory polymorphisms is a key requirement for next-generation human genetic analysis. Here we describe haploChIP, a method that uses chromatin immunoprecipitation (ChIP) and mass s...