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  1. No Access

    Article

    Genomic analysis of local variation and recent evolution in Plasmodium vivax

    Dominic Kwiatkowski and colleagues report a population genomic analysis of 228 clinical samples of Plasmodium vivax from 13 countries, with an emphasis on Southeast Asia. They analyze patterns of genetic structur...

    Richard D Pearson, Roberto Amato, Sarah Auburn, Olivo Miotto… in Nature Genetics (2016)

  2. Article

    Open Access

    Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya

    The relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and clinical phenomena such as primaquine-sensitivity and protection from severe malaria remains poorly defined, with past associati...

    Shivang S Shah, Alex Macharia, Johnstone Makale, Sophie Uyoga… in BMC Medical Genetics (2014)

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  3. No Access

    Article

    Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

    Dominic Kwiatkowski and colleagues report analysis of genetic variation in 826 Plasmodium falciparum samples collected from 10 locations in West Africa and southeast Asia. They characterize the population structu...

    Olivo Miotto, Jacob Almagro-Garcia, Magnus Manske, Bronwyn MacInnis… in Nature Genetics (2013)

  4. Article

    Open Access

    Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes

    The TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA SNPs with T2D but the majority have been small-scale and produced no convincing evidence of asso...

    Vesna Boraska, Nigel W Rayner, Christopher J Groves… in BMC Medical Genetics (2010)

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  5. Article

    Genome-wide and fine-resolution association analysis of malaria in West Africa

    Dominic Kwiatkowski and colleagues of the MalariaGEN and the WTCCC consortiums report a genome-wide analysis of severe malaria in The Gambia. They provide guidance for design of GWAS in African populations, an...

    Muminatou Jallow, Yik Ying Teo, Kerrin S Small, Kirk A Rockett… in Nature Genetics (2009)

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  6. No Access

    Article

    A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility

    The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria...

    Mahamadou Diakite, Taane G. Clark, Sarah Auburn, Susana Campino… in Human Genetics (2009)

  7. No Access

    Article

    Association of the GNAS locus with severe malaria

    Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria parasite at a cellular level. Obstruction of signal transduction via the erythroc...

    Sarah Auburn, Mahamadou Diakite, Andrew E. Fry, Anita Ghansah… in Human Genetics (2008)

  8. No Access

    Article

    In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading

    In vivo characterization of regulatory polymorphisms is a key requirement for next-generation human genetic analysis. Here we describe haploChIP, a method that uses chromatin immunoprecipitation (ChIP) and mass s...

    Julian C. Knight, Brendan J. Keating, Kirk A. Rockett… in Nature Genetics (2003)