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DNA as the main target in radiotherapy—a historical overview from first isolation to anti-tumour immune response

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  1. Article

    Open Access

    Successful implementation of online educational lectures of the German Society for Radiation Oncology (DEGRO)

    Modern digital teaching formats have become increasingly important in recent years, in part due to the COVID-19 pandemic. In January 2021, an online-based webinar series was established by the German Society f...

    Marcel Büttner, Philip Melton, Rainer Fietkau… in Strahlentherapie und Onkologie (2024)

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  2. Article

    Open Access

    Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors

    This review article is intended to provide a perspective overview of potential strategies to overcome radiation resistance of tumors through the combined use of immune checkpoint and DNA repair inhibitors.

    Sandra Classen, Cordula Petersen, Kerstin Borgmann in Strahlentherapie und Onkologie (2023)

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  3. Article

    Open Access

    The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma

    Immune checkpoint inhibition is a therapeutic option in many cancer entities. In head and neck squamous cell carcinoma (HNSCC) targeting of the PD-1/PD-L1 (B7-H1) axis is approved in recurrent/metastatic disea...

    Mara Borgmann, Agnes Oetting, Felix Meyer… in Journal of Cancer Research and Clinical On… (2023)

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  4. Article

    Open Access

    Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L

    Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor control after radiotherapy depends on the eradication of...

    Jacqueline Nathansen, Vasyl Lukiyanchuk, Linda Hein, Maya-Isabel Stolte… in Oncogene (2021)

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  5. Article

    Open Access

    Clonality of circulating tumor cells in breast cancer brain metastasis patients

    The incidence of brain metastases in breast cancer (BCBM) patients is increasing. These patients have a very poor prognosis, and therefore, identification of blood-based biomarkers, such as circulating tumor c...

    Carlotta Riebensahm, Simon A. Joosse, Malte Mohme… in Breast Cancer Research (2019)

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  6. Article

    Open Access

    Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy

    To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position −509), XPD (codon 751), and XRCC1 (codon 399) with the risk of severe erythema after breast cons...

    Annette Raabe, Katharina Derda, Sebastian Reuther, Silke Szymczak… in Radiation Oncology (2012)

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