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  1. Article

    Open Access

    The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes

    Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients. Th...

    Kenji Ikuta, Yuko Waguri-Nagaya, Kae Kikuchi… in Arthritis Research & Therapy (2012)

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    Article

    FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes

    Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities. The purpose of this study was to determine the inhibitory effects of FK506 (tacrolimus) on GLS production i...

    Takaya Yamagami, Yuko Waguri-Nagaya, Kenji Ikuta… in Rheumatology International (2011)

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    Article

    Current status and perspective of angiogenesis and antivascular therapeutic strategy: non-small cell lung cancer

    Lung cancer is the leading cause of cancer death worldwide, and most patients die of metastatic disease. Angiogenesis, namely, neovascularization from preexisting vasculature, is necessary for tumor growth in ...

    Seiji Yano, Yuka Matsumori, Kenji Ikuta… in International Journal of Clinical Oncology (2006)