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Article
Open AccessPhosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism
Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of Parkinson’s disease (PD). However, it has not been fully determined which lipids are involved in the initiation of αSyn...
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Article
Adding heat stress to repeated-sprint training in hypoxia does not enhance performance improvements in canoe/kayak athletes
The present study investigated the effects of adding heat stress to repeated-sprint training in hypoxia on performance and physiological adaptations in well-trained athletes.
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Article
Open AccessMacromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
Dialysis-related amyloidosis (DRA), a serious complication among long-term hemodialysis patients, is caused by amyloid fibrils of β2-microglobulin (β2m). Although high serum β2m levels and a long dialysis vint...
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Article
Open AccessTwo-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease
Parkinson’s disease is a neurodegenerative disease characterized by the formation of neuronal inclusions of α-synuclein in patient brains. As the disease progresses, toxic α-synuclein aggregates transmit throu...
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Article
Effects of combined hot and hypoxic conditions on muscle blood flow and muscle oxygenation during repeated cycling sprints
The purpose of the present study was to determine muscle blood flow and muscle oxygenation during repeated-sprint exercise under combined hot and hypoxic conditions.
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Article
Hepcidin response to three consecutive days of endurance training in hypoxia
The purpose of this study was to determine the effects of 3 consecutive days of endurance training in hypoxia on hepcidin responses.
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Article
Open AccessBreakdown of supersaturation barrier links protein folding to amyloid formation
The thermodynamic hypothesis of protein folding, known as the “Anfinsen’s dogma” states that the native structure of a protein represents a free energy minimum determined by the amino acid sequence. However, i...
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Article
A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that lack therapeutic solutions. Here, we show that the molecular chaperone (N,N′-([cyclohexylmethylene]di-4,1-phenylene)bis(2...
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Chapter and Conference Paper
HTS Millimeter Wave Mixer Antenna-II
We report on high temperature superconducting (HTS) millimeter wave mixer-antenna-IC performances, such as frequency conversion and fundamental / harmonic mixings in the wide frequency range from 10GHz up to m...
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Chapter and Conference Paper
Characteristics of Thin Film YBCO Micro-Stripline Resonator by Laser Etching
The micro-stripline type resonators have been fabricated by YBCO films using maskless laser etching methods. YBCO thin films on MgO(100) substrates are deposited by pulsed excimer laser. In addition, standard ...
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Chapter and Conference Paper
14GHz Y-Ba-Cu-O Microstripline Resonators
High-Tc superconductor(HTS) resonators are reported in this paper. The YBa2Cu3O7-δ(YBCO) films in this work were pulsed laser deposited onto 0.5mm thick [100] MgO substrates. We have developed superconducting 13....
