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within Katrina Olson Remove this filter English Remove this filter Biochemistry, general Remove this filter Biotechnology Remove this filter Pharmacology/Toxicology Remove this filter

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  1. No Access

    Article

    Approaches to Resolve False Reporting in Neutralizing Antibody Assays Caused by Reagent Leaching from Affinity Capture Elution Solid Phase

    Insufficient drug tolerance presents a major challenge in the development of neutralizing antibody (NAb) assays for biotherapeutics. Sample pre-treatment using solid-phase extraction with acid dissociation (SP...

    Yuhong **ang, John Kamerud, Jean Donley, Katrina Olson, Teresa Caiazzo… in The AAPS Journal (2018)

  2. No Access

    Article

    Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody

    Immunogenicity is a major challenge for protein therapeutics which can potentially reduce drug efficacy and safety and is often being monitored by anti-drug antibody (ADA) and neutralizing antibody (NAb) assay...

    Yuhong **ang, Chuenlei Parng, Katrina Olson, Elena Seletskaia… in The AAPS Journal (2019)