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Article
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
Classically activated macrophages are targets of intracellular bacteria such as Mycobacteria tuberculosis. Murray and colleagues find that such pathogens induce arginase 1 in these macrophages to block the produc...
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Article
Developmental origins of NAFLD: a womb with a clue
Exposure to maternal overnutrition or undernutrition increases susceptibility to NAFLD in childhood and hastens progression to NASH across the lifespan, especi...
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Article
Open AccessMacrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis
In infants intolerant of enteral feeding because of intestinal disease, parenteral nutrition may be associated with cholestasis, which can progress to end-stage liver disease. Here we show the function of hepa...
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Article
Open AccessThe gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant ...
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Article
Open AccessAuthor Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessIL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
IL-36, which belongs to the IL-1 superfamily, is increasingly linked to neutrophilic inflammation. Here, we combined in vivo and in vitro approaches using primary mouse and human cells, as well as, acute and c...
