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  1. Article

    Open Access

    Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans

    Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic inflammation. Traditional strategies primarily focus on lipid redu...

    Lin Fan, Junwei Liu, Wei Hu, Zexin Chen, Jie Lan, Tongtong Zhang in Cell Research (2024)

  2. Article

    Open Access

    Dietary supplemental coated essential oils and organic acids mixture improves growth performance and gut health along with reduces Salmonella load of broiler chickens infected with Salmonella Enteritidis

    Reducing Salmonella infection in broiler chickens by using effective and safe alternatives to antibiotics is vital to provide safer poultry meat and minimize the emergence of drug-resistant Salmonella and the spr...

    Zeqiong Hu, Lin Liu, Fangshen Guo, Jia Huang in Journal of Animal Science and Biotechnology (2023)

  3. Article

    Open Access

    Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing

    This study aims to give a new perspective to the biomarkers in the lung adenocarcinoma (LUAD) brain metastasis, pathways involved and potential therapeutics. We performed a comprehensive single-cell level tran...

    Mingyu Chen, Hanyue Li, **aolin Xu, Xunxia Bao, Lei Xue, **nghao Ai in Cell Death & Disease (2023)

  4. No Access

    Article

    The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation

    CRISPR-Cas modules serve as the adaptive nucleic acid immune systems for prokaryotes, and provide versatile tools for nucleic acid manipulation in various organisms. Here, we discovered a new miniature type V ...

    Ao Sun, Cheng-** Li, Zhihang Chen, Shouyue Zhang, Dan-Yuan Li, Yun Yang in Cell Research (2023)

  5. Article

    Open Access

    Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens

    Preventing Salmonella infection and colonization in young birds is key to improving poultry gut health and reducing Salmonella contamination of poultry products and decreasing salmonellosis for human consumption ...

    Yu**g Shao, Wenrui Zhen, Fangshen Guo in Journal of Animal Science and Biotechnology (2022)

  6. Article

    Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units

    Dong Wu, Kaichen Zhou, Meng **ao, Zhihua Liu, Shuyang Zhang in Science China Life Sciences (2022)

  7. Article

    Open Access

    Critical steps to tumor metastasis: alterations of tumor microenvironment and extracellular matrix in the formation of pre-metastatic and metastatic niche

    For decades, cancer metastasis has been a heated topic for its high mortality. Previous research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in cancer metastasis, assisting...

    Jianan Zhuyan, Mingyu Chen, Tianhao Zhu, Xunxia Bao, Timing Zhen in Cell & Bioscience (2020)