88 Result(s)
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Article
Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
Two groups this week show that embryonic nerves rely on unexpected sensory devices to guide their growth. The findings help to build a picture of how brains get wired. Ion channels formed by transient receptor...
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China's grain relies on foreign fertilizer
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Unfavourable environment limits social conflict in Yuhina brunneiceps
Identifying the factors that modulate cooperative and competitive behaviours is the key to understanding social evolution. However, how ecological factors affect social conflict and their fitness consequences ...
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Article
Open AccessEnhanced Community Structure Detection in Complex Networks with Partial Background Information
Community structure detection in complex networks is important since it can help better understand the network topology and how the network works. However, there is still not a clear and widely-accepted defini...
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Open AccessVAV3 Oncogene Expression in Colorectal Cancer: Clinical Aspects and Functional Characterization
Although colorectal cancer (CRC) is one of the most common malignancies worldwide, the current therapeutic approaches for advanced CRC are ineffective. In this study, we investigated the involvement of the VAV3 o...
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miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β
As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as th...
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Open AccessExome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn’s disease patients
Previous studies have highlighted the role of genetic predispositions in disease and several genes had been identified as important in Crohn’s disease (CD). However, many of these genes are likely rare and not...
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Open AccessAnchor-based classification and type-C inhibitors for tyrosine kinases
Tyrosine kinases regulate various biological processes and are drug targets for cancers. At present, the design of selective and anti-resistant inhibitors of kinases is an emergent task. Here, we inferred spec...
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Open AccessQiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode
The present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in Chinese medicine, QiShenYiQi Pills (QSYQ) and the contributions of its components to the effect in rat...
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Open AccessCutting improves the productivity of lucerne-rich stands used in the revegetation of degraded arable land in a semi-arid environment
Understanding the relationships between vegetative and environmental variables is important for revegetation and ecosystem management on the Loess Plateau, China. Lucerne (Medicago sativa L.) has been widely used...
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Open AccessEfficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition
Human pluripotent stem cells (hPSCs) have potential to differentiate to unlimited number of neural cells, which provide powerful tools for neural regeneration. To date, most reported protocols were established...
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Open AccessPyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
In cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinas...
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Open AccessNotch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells
Rapidly cycling LGR5+ intestinal stem cells (ISCs) located at the base of crypts are the primary driver of regeneration. Additionally, BMI1 expression is correlated with a slow cycling pool of ISCs located at ...
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Open AccessWhite spot syndrome virus entry is dependent on multiple endocytic routes and strongly facilitated by Cq-GABARAP in a CME-dependent manner
White spot syndrome virus (WSSV) is a lethal pathogen of shrimp and many other crustaceans, including crayfish. However, the molecular mechanism underlying its cellular entry remains elusive due to the lack of...
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Open AccessOral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus
High salt intake leads to an increase in some proinflammatory cytokines and neurotransmitters involved in the pathogenesis of hypertension. The purpose of this work was to know if oral administration of anti-o...
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Open AccessReproductive toxicity and gender differences induced by cadmium telluride quantum dots in an invertebrate model organism
Sexual glands are key sites affected by nanotoxicity, but there is no sensitive assay for measuring reproductive toxicity in animals. The aim of this study was to investigate the toxic effects of cadmium tellu...
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Open AccessReduced incidence of interstitial pneumonitis after allogeneic hematopoietic stem cell transplantation using a modified technique of total body irradiation
Allogeneic hematopoietic stem cell transplantation is a curative-intent treatment for patients with high-risk hematologic diseases. However, interstitial pneumonitis (IP) and other toxicities remain major conc...
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Open AccessPotential effects of climate change on geographic distribution of the Tertiary relict tree species Davidia involucrata in China
This study, using species distribution modeling (involving a new approach that allows for uncertainty), predicts the distribution of climatically suitable areas prevailing during the mid-Holocene, the Last Gla...
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Open AccessHigh photon-to-heat conversion efficiency in the wavelength region of 250–1200 nm based on a thermoelectric Bi2Te3 film structure
In this work, 4-layered SiO2/Bi2Te3/SiO2/Cu film structures were designed and fabricated and the optical properties investigated in the wavelength region of 250–1200 nm for their promising applications for direct...
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Open AccessGinsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway
Cardiac ischemia and reperfusion (I/R) injury remains a challenge for clinicians. Ginsenoside Rb1 (Rb1) has been reported to have the ability to attenuate I/R injury, but its effect on energy metabolism during...
