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  1. No Access

    Article

    CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers

    CYP3A5 expression is regulated by single-nucleotide polymorphisms (SNPs). The CYP3A5 genotype might contribute to a marked interindividual variation in CYP3A-mediated metabolism of drugs. Nifedipine is a typic...

    T Fukuda, S Onishi, S Fukuen, Y Ikenaga, M Ohno, K Hoshino… in The Pharmacogenomics Journal (2004)

  2. No Access

    Article

    Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism

    Background: Little is known about differences in the disposition kinetics and pharmacological effects on gastrin levels between lansoprazole and rabeprazole given in a repeated dosing scheme with respect to the ...

    I. Ieiri, Y. Kishimoto, H. Okochi, K. Momiyama… in European Journal of Clinical Pharmacology (2001)