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    Article

    CYP2C19 polymorphism effect on phenobarbitone

    Objective: The aim of this study was to clarify the effect of genetic polymorphisms of CYP2C19 on the pharmacokinetics of phenobarbitone (PB) using a nonlinear mixed-effects model (NONMEM) analysis in Japanese a...

    K. Mamiya, A. Hadama, E. Yukawa, I. Ieiri… in European Journal of Clinical Pharmacology (2000)