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  1. No Access

    Article

    Coherent dynamics of a flux qubit coupled to a harmonic oscillator

    In the emerging field of quantum computation1 and quantum information, superconducting devices are promising candidates for the implementation of solid-state quantum bits (qubits). Single-qubit operations2,3,4,5,

    I. Chiorescu, P. Bertet, K. Semba, Y. Nakamura, C. J. P. M. Harmans, J. E. Mooij in Nature (2004)

  2. No Access

    Chapter

    Dynamics of a Qubit Coupled to a Harmonic Oscillator

    We present experimental results showing the coherent dynamics of a flux-qubit coupled to the plasma mode of its measuring DC-SQUID. Resonances corresponding to transitions where both the qubit and the oscillat...

    P. Bertet, I. Chiorescu, K. Semba… in Quantum Computing in Solid State Systems (2006)

  3. No Access

    Article

    Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin

    The Wnt signaling pathway is essential for embryonic development and carcinogenesis. Upon Wnt stimulation, β-catenin is stabilized and associates with T-cell factor or lymphoid enhancing factor, thereby activatin...

    K Haraguchi, M Ohsugi, Y Abe, K Semba, T Akiyama, T Yamamoto in Oncogene (2008)

  4. Article

    Two-photon probe of the Jaynes–Cummings model and controlled symmetry breaking in circuit QED

    Micrometre-scale superconducting circuits can act as quantum two-level systems, but unlike in their natural counterparts—such as atoms—the parameters of these ‘artificial qubits’ can be controlled externally. ...

    Frank Deppe, Matteo Mariantoni, E. P. Menzel, A. Marx, S. Saito… in Nature Physics (2008)

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  5. No Access

    Article

    Quantum state control, entanglement, and readout of the Josephson persistent-current qubit

    Quantum state control including entanglement, and readout of the Josephson persistent-current qubit, flux qubit, are reviewed. First, we mention our single-shot readout of quantum superposition state of a flux...

    K. Semba, J. Johansson, K. Kakuyanagi, H. Nakano… in Quantum Information Processing (2009)

  6. Article

    Open Access

    TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

    Epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair and cancer progression in adult tissues. We have recently shown that transforming growth factor (TGF)-β-induced EMT in...

    K Horiguchi, K Sakamoto, D Koinuma, K Semba, A Inoue, S Inoue, H Fujii… in Oncogene (2012)

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  7. No Access

    Article

    Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

    The epidermal growth factor receptor (EGFR) has an essential role in multiple signaling pathways, including cell proliferation and migration, through extracellular ligand binding and subsequent activation of i...

    S Yoshikawa, M Kukimoto-Niino, L Parker, N Handa, T Terada, T Fujimoto… in Oncogene (2013)

  8. Article

    Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury

    Optic nerve injury (ONI) induces retinal ganglion cell (RGC) death and optic nerve atrophy that lead to visual loss. Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated...

    T Katome, K Namekata, X Guo, K Semba, D Kittaka, K Kawamura… in Cell Death & Differentiation (2013)

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  9. Article

    Open Access

    Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma

    Glaucoma is one of the leading causes of irreversible blindness that is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-ac...

    K Semba, K Namekata, A Kimura, C Harada, Y Mitamura, T Harada in Cell Death & Disease (2014)

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  10. Article

    Open Access

    Renin–angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma

    Glaucoma, one of the leading causes of irreversible blindness, is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino acid car...

    K Semba, K Namekata, X Guo, C Harada, T Harada, Y Mitamura in Cell Death & Disease (2014)

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  11. No Access

    Article

    GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm

    Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and K...

    K Taki, M Ohmuraya, E Tanji, H Komatsu, D Hashimoto, K Semba, K Araki… in Oncogene (2016)

  12. No Access

    Article

    An in vivo screening system to identify tumorigenic genes

    Screening for oncogenes has mostly been performed by in vitro transformation assays. However, some oncogenes might not exhibit their transforming activities in vitro unless putative essential factors from in vivo

    T Ihara, Y Hosokawa, K Kumazawa, K Ishikawa, J Fujimoto, M Yamamoto… in Oncogene (2017)

  13. Article

    Open Access

    Hamiltonian of a flux qubit-LC oscillator circuit in the deep–strong-coupling regime

    We derive the Hamiltonian of a superconducting circuit that comprises a single-Josephson-junction flux qubit inductively coupled to an LC oscillator, and we compare the derived circuit Hamiltonian with the qua...

    F. Yoshihara, S. Ashhab, T. Fuse, M. Bamba, K. Semba in Scientific Reports (2022)

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