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Open AccessDeletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse
JMJD2B is a histone demethylase enzyme that regulates gene expression through demethylation of H3K9me3. Although mutations of JMJD2B have been suggested to be responsible for neurodevelopmental disorders, the ...
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Article
Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus
Norepinephrine turnover rate in the murine locus coeruleus (LC) is known to be enhanced by the intraperitoneal (i.p.) injection of lipopolysaccharide (LPS). Approximately 40% of LC neurons are also known to p...
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Article
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine (DA) biosynthesis.1,2 Exon 3 of the human TH gene encodes the sequence from Ser31 to Glu104 of type 1 enzyme,3,4 which contains the critical parts...
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Article
Calcitonin gene-related peptide- and substance P-immunoreactive axons in the nucleus gracilis of the rat with special reference to axonal dystrophy: light and electron microscopic observations
Calcitonin gene-related peptide (CGRP) and substance P (SP)-immunoreactive (IR) axons in the nucleus gracilis of normal rats (1–15 months of age) were studied by light and electron microscopy. Besides many CGR...
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Article
Further confirmation of serotonin reduction in the neostriatum during hyperthermia-induced convulsions: a quantitative immunohistochemical study
Changes occurring in serotonin neurons during hyperthermia and hyperthermia-induced convulsions were examined by quantiative immunohistochemistry. A marked increase in serotonin immunoreactivity was observed a...
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Article
Serotonin reduction in the mouse neostriatum during hyperthermia-induced convulsions studied by immunohistochemistry
Changes occurring in serotonin neurons during hyperthermia-induced convulsions were examined by means of a modified immunohistochemical method. All mice (8–12 weeks of age) exposed to the temperature of 50°C h...
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Article
Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier
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Sodium fluorescein and Evans Blue, commonly used tracers in the study of blood-brain barrier disturbances, re...
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Sequential delayed enhanced CT in brain tumors
Delayed enhanced CT was performed in 53 cases and these findings are compared with those of delayed radioisotope scan and with operative and histopathologic findings. We have classified the results of enhancem...
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Article
Diagnostic value of CT cisternography with intrathecal metrizamide enhancement, comparison with isotope cisternography
Metrizamide CT cisternography (CTC) was performed for the evaluation of CSF dynamics and the diagnosis of skull-base tumors. Results of CTC in 52 cases examined for the study of CSF dynamics correlated well wi...
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Article
The venous drainage of the tectum mesencephali
The normal course and appearance of the veins draining the tectum mesencephali proper are described in detail on the basis of the anatomical radiological study. These specific veins, the quadrigeminal veins, were...