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  1. Article

    Response on: Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice (Miyata S. et al., Psychopharmacology, 2009)

    Masahiro Ohsawa, Junzo Kamei in Psychopharmacology (2011)

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    Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice

    The traditional antihistamine chlorpheniramine ameliorates panic attacks, phobias, and lowered mood, and this therapeutic effect is independent of the blockade of histamine H1 receptors. Since chlorpheniramine in...

    Shigeo Miyata, Shoko Hirano, Masahiro Ohsawa, Junzo Kamei in Psychopharmacology (2011)

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    Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats

    It has been reported that many of the behavioral and serotonergic neuronal changes observed in olfactory bulbectomy (OBX) were improved by subchronic administration of a variety of antidepressants.

    Akiyoshi Saitoh, Kazumasa Yamaguchi, Yoshimi Tatsumi… in Psychopharmacology (2007)

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    ROCK inhibition produces anxiety-related behaviors in mice

    The role of Rho/Rho-associated kinase (ROCK) in regulating dendritic and axonal morphology during development has gained much attention. Very little is known, however, about the role of the Rho/ROCK pathway in...

    Akiyoshi Saitoh, Mitsuhiko Yamada, Misa Yamada, Shinya Kobayashi… in Psychopharmacology (2006)

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    Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice

    We previously reported that the head-twitch responses induced by the 5-HT2 receptor agonist (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) (DOI-HTRs) were decreased in streptozotocin-induced diabetic mice.

    Shigeo Miyata, Shoko Hirano, Junzo Kamei in Psychopharmacology (2006)

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    Role of δ-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats

    Recent studies have shown that endogenous opioid systems are associated with the regulation of emotional responses. In particular, it has been reported that δ-opioid receptors act naturally to inhibit stress a...

    Akiyoshi Saitoh, Yuji Yoshikawa, Kenji Onodera, Junzo Kamei in Psychopharmacology (2005)

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    Diabetes inhibits the DOI-induced head-twitch response in mice

    Clinical studies suggest that the prevalence of psychiatric disorders is higher in diabetic patients than in the general population. It has been reported that central serotonin2A (5-HT2A) receptors may be involve...

    Shigeo Miyata, Shoko Hirano, Junzo Kamei in Psychopharmacology (2004)

  8. Article

    Diabetes Attenuates the Antidepressant-Like Effect Mediated by the Activation of 5-HT1A Receptor in the Mouse Tail Suspension Test

    Several lines of evidence have indicated that the prevalence of depression in diabetic subjects is higher than that in the general population, however, little information is available on the effects of antidep...

    Shigeo Miyata, Shoko Hirano, Junzo Kamei in Neuropsychopharmacology (2004)

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    Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice

    Little information is available about the interaction between dihydrocodeine and second-generation antihistamine drugs such as cetirizine and ebastine, with particular reference to the rewarding effect of dihy...

    Junzo Kamei, Kayo Morita, Shigeo Miyata, Kenji Onodera in Psychopharmacology (2003)

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    Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice

    To test our hypothesis that the abnormally low efficacy of μ-opioid agonists in diabetic mice may be due to functional changes in ATP-sensitive potassium channels, we evaluated the effects of cromakalim on the...

    Junzo Kamei, Naoya Kawashima, Minoru Narita, Tsutomu Suzuki… in Psychopharmacology (1994)

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    The effect of chronic treatment with naltrindole, a selective δ-opioid antagonist, on μ-opioid receptor-mediated antinociception in diabetic mice

    The effects of chronic treatment with naltrindole (NTI), a selective δ-opioid receptor antagonist, on the antinociceptive effects of μ-opioid agonists, such as morphine and [D-Ala2,N-MePhe4, Gly-ol5]enkephalin (D...

    Junzo Kamei, Naoya Kawashima, Yuriko Iwamoto, Tsutomu Suzuki… in Psychopharmacology (1993)

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    δ-Opiod receptor-mediated forced swimming stress-induced antinociception in the formalin test

    Forced swimming stress-induced antinociception (FSSIA) was assessed using the formalin test. Male ICR mice, weighing about 30 g, were forced to swin in water at 20°C for 3 min. In unstressed mice, SC injection...

    Junzo Kamei, Hideki Hitosugi, Miwa Misawa, Hiroshi Nagase… in Psychopharmacology (1993)

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    Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice

    ICV cromakalim, a K+ channel opener, produced antinociception. This effect was completely antagonized by ICV glibenclamide, a selective adenosine triphosphate-sensitive K+ channel (KATP channel) blocker. Furtherm...

    Minoru Narita, Kazuaki Takamori, Naoya Kawashima, Masahiko Funada… in Psychopharmacology (1993)