19 Result(s)

Article

Hepatic artery infusion chemotherapy combined with camrelizumab plus rivoceranib for hepatocellular carcinoma with portal vein tumor thrombosis: a multicenter propensity score-matching analysis

Portal vein tumor thrombosis (PVTT) signifies late-stage hepatocellular carcinoma (HCC) with high-risk progression and poor prognosis. As a standard treatment, sorafenib monotherapy has limited the efficacy in...

Yangyang Li, Jiandong Guo, Wendao Liu, Hua** Pang, Yipei Song… in Hepatology International (2024)

Article

3D-printed PCL framework assembling ECM-inspired multi-layer mineralized GO-Col-HAp microscaffold for in situ mandibular bone regeneration

In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for bone tissue engineering. However, the challenge of creating scaffolds that mimic n...

Yanqing Yang, Huan He, Fang Miao, Mingwei Yu, **xi Wu… in Journal of Translational Medicine (2024)

Article

Prognosis prediction and risk stratification of transarterial chemoembolization or intraarterial chemotherapy for unresectable hepatocellular carcinoma based on machine learning

To develop and validate a risk scoring scale model (RSSM) for stratifying prognostic risk after intra-arterial therapies (IATs) for hepatocellular carcinoma (HCC).

Wendao Liu, Ran Wei, Junwei Chen, Yangyang Li, Hua** Pang… in European Radiology (2024)

Article

Construction of a prediction model for rebleeding in patients with acute upper gastrointestinal bleeding

The incidence of rebleeding in patients with upper gastrointestinal bleeding (UGIB) remains despite advances in intervention approaches. Therefore, early prediction of the risk of rebleeding could help to grea...

Yang** Zhuang, Shaohuai **a, Junwei Chen, Jun Ke… in European Journal of Medical Research (2023)

Article

Safety, efficacy, and survival of drug-eluting beads-transarterial chemoembolization vs. conventional-transarterial chemoembolization in advanced HCC patients with main portal vein tumor thrombus

To compare the efficacy, overall survival (OS) and safety of drug-eluting beads-TACE (DEB-TACE) and C-TACE as initial treatment in advanced hepatocellular carcinoma (HCC) patients with main portal vein tumor t...

Junwei Chen, Lisha Lai, Churen Zhou, Junyang Luo, Haofan Wang, Mingan Li… in Cancer Imaging (2023)

Article

Selective venous sampling in primary hyperparathyroidism caused by ectopic parathyroid gland: a case report and literature review

As an invasive technique, selective venous sampling (SVS) is considered a useful method to identify a lesion’s location to increase the success rate of secondary surgery in patients with primary hyperparathyro...

Xubin Yang, Xueyan Chen, Huan Xu, Junwei Chen, Bin Yao… in BMC Endocrine Disorders (2023)

Article

DEM-TACE as the initial treatment could improve the clinical efficacy of the hepatocellular carcinoma with portal vein tumor thrombus: a retrospective controlled study

Conventional-transarterial chemoembolization (C-TACE) was proven to improve overall survival (OS) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT), drug-eluting microsphere-TAC...

Junwei Chen, Lisha Lai, Junyang Luo, Haofan Wang, Mingan Li, Mingsheng Huang in BMC Cancer (2022)

Article

Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway

Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate ...

Feng Qi, Wenxing Qin, Yao Zhang, Yongde Luo… in Journal of Experimental & Clinical Cancer … (2021)

Article

Nanoarray heterojunction and its efficient solar cells without negative impact of photogenerated electric field

Efficient, stable and low-cost solar cells are being desired for the photovoltaic conversion of solar energy into electricity for sustainable energy production. Nanorod/nanowire arrays of narrow-bandgap semico...

Rong Liu, Zhitao Shen, Zhiyang Wan, Liangxin Zhu, Junwei Chen… in Communications Physics (2021)

Article

Author Correction: Soft fibrin gels promote selection and growth of tumorigenic cells

**g Liu, Youhua Tan, Huafeng Zhang, Yi Zhang, **wei Xu, Junwei Chen… in Nature Materials (2021)

Article

Preferentially oriented large antimony trisulfide single-crystalline cuboids grown on polycrystalline titania film for solar cells

Photovoltaic conversion of solar energy into electricity is an alternative way to use renewable energy for sustainable energy production. The great demand of low-cost and efficient solar cells inspires researc...

Junwei Chen, Juanjuan Qi, Rong Liu, **aoguang Zhu, Zhiyang Wan… in Communications Chemistry (2019)

Article

Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients

The development of Systemic lupus erythematosus (SLE) has been associated with the balance of Th17 and Treg cells. IL-2 and rapamycin can influence the populations of both Th17 and Treg cells. However, it is u...

Chunmiao Zhao, Yanfang Chu, Zhaoyun Liang, Bingying Zhang, Xuxia Wang… in BMC Immunology (2019)

Article

Quantifying compressive forces between living cell layers and within tissues using elastic round microgels

Increasing evidence shows that mechanical stresses are critical in regulating cell functions, fate, and diseases. However, no methods exist that can quantify isotropic compressive stresses. Here we describe fl...

Erfan Mohagheghian, Junyu Luo, Junjian Chen, Gaurav Chaudhary… in Nature Communications (2018)

Article

Inhibition of cancer stem cell like cells by a synthetic retinoid

Develo** novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe a novel synthetic retinoid, namely WYC-209, which inhibits p...

Junwei Chen, **n Cao, Quanlin An, Yao Zhang, Ke Li, Wenting Yao… in Nature Communications (2018)

Article

Survival benefit of chemoembolization plus Iodine125 seed implantation in unresectable hepatitis B-related hepatocellular carcinoma with PVTT: a retrospective matched cohort study

To investigate the survival benefit of transarterial chemoembolization (TACE) plus Iodine125 seed implantation (TACE-Iodine125) in hepatitis B-related HCC patients with portal vein tumour thrombus (PVTT) and t...

Mingsheng Huang, Qu Lin, Haofan Wang, Junwei Chen, Mingjun Bai… in European Radiology (2016)

Article

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

Develo** novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to improve outcomes of cancer patients. Here we show an i...

**gwei Ma, Yi Zhang, Ke Tang, Huafeng Zhang, **aonan Yin, Yong Li… in Cell Research (2016)

Article

Efficient extravasation of tumor-repopulating cells depends on cell deformability

Cancer metastasis is the most deadly stage in cancer progression. Despite significant efforts over the past decades, it remains elusive why only a very small fraction of cancer cells is able to generate microm...

Junjian Chen, Wenwen Zhou, Qiong Jia, Junwei Chen, Shuang Zhang… in Scientific Reports (2016)

Article

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

Tumour-repopulating cells (TRCs) are a self-renewing, tumorigenic subpopulation of cancer cells critical in cancer progression. However, the underlying mechanisms of how TRCs maintain their self-renewing capab...

Youhua Tan, Arash Tajik, Junwei Chen, Qiong Jia, Farhan Chowdhury… in Nature Communications (2014)

Article

Generation of organized germ layers from a single mouse embryonic stem cell

Mammalian inner cell mass cells undergo lineage-specific differentiation into germ layers of endoderm, mesoderm and ectoderm during gastrulation. It has been a long-standing challenge in developmental biology ...

Yeh-Chuin Poh, Junwei Chen, Ying Hong, Haiying Yi, Shuang Zhang… in Nature Communications (2014)