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Article
Open AccessA conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
Picornaviral IRES elements are essential for initiating the cap-independent viral translation. However, three-dimensional structures of these elements remain elusive. Here, we report a 2.84-Å resolution crysta...
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Article
Open AccessStructural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif
The DIR2s RNA aptamer, a second-generation, in-vitro selected binder to dimethylindole red (DIR), activates the fluorescence of cyanine dyes, DIR and oxazole thiazole blue (OTB), allowing detection of two well...
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Article
Open AccessSynthesizing topological structures containing RNA
Though knotting and entanglement have been observed in DNA and proteins, their existence in RNA remains an enigma. Synthetic RNA topological structures are significant for understanding the physical and biolog...