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Article
Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medications, and personal care products due to their broad-spectrum antibacterial and antifun...
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Article
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system
This study investigated whether protein arginine methyltransferase (PRMT) and the cannabinoid system are involved in cisplatin-induced ototoxicity. Cisplatin increased cytosine–cytosine–adenosine–adenosine–thy...
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Article
Role of Klotho, an antiaging protein, in pulmonary fibrosis
Klotho is a recently discovered antiaging protein. Although many researchers are investigating the roles of Klotho in chronic kidney diseases and cancer, however, there are no studies on the roles of Klotho in...
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Article
Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats
The present study investigated the protective effects of melatonin (MT) against gentamicin (GM)-induced nephrotoxicity and oxidative stress in rats. We also investigated the effects of MT on induction of apopt...
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Article
Immunohistochemical analysis of cAMP response element-binding protein in mouse testis during postnatal development and spermatogenesis
Basal activity and cellular localization of cAMP response element-binding protein (CREB) was examined in mouse testis during postnatal development and spermatogenesis. Testes of ICR mice sampled on postnatal d...
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Article
Embryo lethality and teratogenicity of a new fluoroquinolone antibacterial DW-116 in rats
DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to i...