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Article
Quality-of-life assessment in patients with bladder cancer
Surgical treatments for bladder cancer are associated with long-term morbidities that affect bladder and sexual function. This Review on health-related quality of life (HRQOL) examines the important issues sur...
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Article
Open AccessMetformin use and prostate cancer in Caucasian men: results from a population-based case–control study
Metformin is a commonly used medication for type II diabetes mellitus. Epidemiologic studies have suggested a decreased relative risk of cancer with metformin use, and preclinical studies of prostate cancer (P...
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Article
Prostate cancer risk stratification by genotype and PSA
The use of PSA testing as a screening tool for prostate cancer is limited by its low specificity. New data offer insight into how genotypic information might be incorporated into PSA screening approaches to en...
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Article
Hospital volume and 90-day mortality risk after radical cystectomy: a population-based cohort study
Hospital cystectomy volume has been associated with in-hospital perioperative mortality in previous studies. In this study, we examine the relationship between hospital cystectomy volume and 90-day mortality i...
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Article
Coffee and tea consumption in relation to prostate cancer prognosis
Bioactive compounds found in coffee and tea may delay the progression of prostate cancer.
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Article
Open AccessEpigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy
Identifying the subset of patients with clinically localized prostate cancer (PCa) at the highest risk of recurrence remains challenging, and better prognostic markers are needed. Gleason score is the best pre...
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Article
Open AccessLong non-coding RNAs identify a subset of luminal muscle-invasive bladder cancer patients with favorable prognosis
Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease, and gene expression profiling has identified several molecular subtypes with distinct biological and clinicopathological characteristics. While...
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Article
The development and comparative effectiveness of a patient-centered prostate biopsy report: a prospective, randomized study
The prostate biopsy pathology report represents a critical document used for decision-making in patients diagnosed with prostate cancer, yet the content exceeds the health literacy of most patients. We sought ...
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Article
Copy number alterations are associated with metastatic-lethal progression in prostate cancer
Aside from Gleason score few factors accurately identify the subset of prostate cancer (PCa) patients at high risk for metastatic progression. We hypothesized that copy number alterations (CNAs), assessed usin...
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Article
Open AccessA bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid culture
Bladder cancer is among the most prevalent cancers worldwide. Currently, few bladder cancer models have undergone thorough characterization to assess their fidelity to patient tumors, especially upon propagati...
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Article
Open AccessAssociation of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer
To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).
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Article
Multicenter evaluation of neoadjuvant and induction gemcitabine–carboplatin versus gemcitabine–cisplatin followed by radical cystectomy for muscle-invasive bladder cancer
Cisplatin-based chemotherapy followed by radical cystectomy (RC) is recommended in patients with muscle-invasive bladder cancer (MIBC). However, up to 50% of patients are cisplatin ineligible. The aim of this ...
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Article
Open AccessA combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer
Available genetically defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Here, we describe a combinatorial genetic strategy applied t...
