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Genome remodelling in a basal-like breast cancer metastasis and xenograft

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  1. Article

    Open Access

    Whole-genome analysis informs breast cancer response to aromatase inhibition

    To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant ar...

    Matthew J. Ellis, Li Ding, Dong Shen, **gqin Luo, Vera J. Suman, John W. Wallis in Nature (2012)

  2. Article

    Open Access

    Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

    The sequencing of AML genomes of eight patients before and after relapse reveals two major patterns of clonal evolution, with chemotherapy appearing to have a role in both patterns.

    Li Ding, Timothy J. Ley, David E. Larson, Christopher A. Miller in Nature (2012)