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  1. No Access

    Article

    Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

    The radiosensitizing effect of caffeine has been associated with the disruption of multiple DNA damage-responsive cell cycle checkpoints, but several lines of evidence also implicate inhibition of DNA repair. ...

    Nesrin A Asaad, Zhao-Chong Zeng, Jun Guan, John Thacker, George Iliakis in Oncogene (2000)

  2. No Access

    Article

    Genetic interactions between RAD51 and its paralogues for centrosome fragmentation and ploidy control, independently of the sensitivity to genotoxic stresses

    We evaluate here whether RAD51 and its paralogues XRCC2 and XRCC3 act via a common pathway for sensitivity to genotoxic stress, centrosome fragmentation and chromosome stability. We expressed the RAD51 dominan...

    Fayza Daboussi, John Thacker, Bernard S Lopez in Oncogene (2005)