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Article
Iron deficiency and supplementation in heart failure
Non-anaemic iron deficiency (NAID) is a strategic target in cardiovascular medicine because of its association with a range of adverse effects in various conditions. Endeavours to tackle NAID in heart failure ...
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Article
Open AccessGlycaemic control and insulin therapy are significant confounders of the obesity paradox in patients with heart failure and diabetes mellitus
A high body mass index (BMI) confers a paradoxical survival benefit in patients with heart failure (HF) or diabetes mellitus (DM). There is, however, controversy whether an obesity paradox is also present in p...
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Article
Open AccessAssociation of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
Growth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone binding protein (GHBP) and, for patients with chronic disease, is ass...
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Article
Defining iron deficiency in patients with heart failure
For patients with heart failure and reduced left ventricular ejection fraction, intravenous iron is likely to deliver clinical and prognostic benefits for those with anaemia and transferrin saturation <20%, es...
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Article
Open AccessImplanted haemodynamic telemonitoring devices to guide management of heart failure: a review and meta-analysis of randomised trials
Congestion is a key driver of morbidity and mortality in heart failure. Implanted haemodynamic monitoring devices might allow early identification and management of congestion. Here, we provide a state-of-the-...
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Article
Open AccessInferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity
A high, Doppler-derived, tricuspid regurgitation velocity (TRV) indicates pulmonary hypertension, which may contribute to right ventricular dysfunction and worsening tricuspid regurgitation leading to systemic...
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Article
Open AccessSystemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ...
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Article
Open AccessAssessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease
Recurrent myocardial ischemia can lead to left ventricular (LV) dysfunction in patients with coronary artery disease (CAD). In this observational cohort study, we assessed for chronic metabolomic and transcrip...
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Article
Open AccessCorrection: Diuretic dose trajectories in dilated cardiomyopathy: prognostic implications
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Open AccessDiuretic dose trajectories in dilated cardiomyopathy: prognostic implications
For patients with heart failure, prescription of loop diuretics (LD) and of higher doses are associated with an adverse prognosis. We investigated LD dose trajectories and their associations with outcomes in p...
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Article
Early and late renal function changes with spironolactone in patients at risk of develo** heart failure: findings from the HOMAGE trial
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Article
Open AccessBiomarkers as predictors of recurrence of atrial fibrillation post ablation: an updated and expanded systematic review and meta-analysis
A high proportion of patients undergoing catheter ablation (CA) for atrial fibrillation (AF) experience recurrence of arrhythmia. This meta-analysis aims to identify pre-ablation serum biomarker(s) associated ...
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Article
Open AccessInfluence of receptor selectivity on benefits from SGLT2 inhibitors in patients with heart failure: a systematic review and head-to-head comparative efficacy network meta-analysis
Receptor selectivity of sodium-glucose cotransporter-2 inhibitors (SGLT2i) varies greatly between agents. The overall improvement of cardiovascular (CV) outcomes in heart failure (HF) patients varies between t...
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Article
Open AccessPrognostic value of the chest X-ray in patients hospitalised for heart failure
Patients admitted to hospital with heart failure will have had a chest X-ray (CXR), but little is known about their prognostic significance. We aimed to report the prevalence and prognostic value of the initia...
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Article
Open AccessComparative efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for cardiovascular outcomes in type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve cardiovascular outcomes in patients with type 2 diabetes mellitus (T2D). The comparative efficacy of individual SGLT2i remains unclear. We searched Pu...
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Article
Open AccessUnder-recognition of heart failure in patients with atrial fibrillation and the impact of gender: a UK population-based cohort study
Patients with atrial fibrillation (AF) complicated by heart failure (HF) have a poor prognosis. We investigated whether long term loop-diuretic therapy in patients with AF and no known diagnosis of HF, as a po...
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Article
Open AccessProteomic mechanistic profile of patients with diabetes at risk of develo** heart failure: insights from the HOMAGE trial
Patients with diabetes mellitus (DM) are at increased risk of develo** heart failure (HF). The “Heart OMics in AGEing” (HOMAGE) trial suggested that spironolactone had beneficial effect on fibrosis and cardi...
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Article
A novel treatment for heart failure targets myocardial fibrosis
A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection...
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Article
Open AccessIntravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials
The recent AFFIRM-AHF trial assessing the effect of intravenous (IV) iron on outcomes in patients hospitalised with worsening heart failure who had iron deficiency (ID) narrowly missed its primary efficacy end...
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Article
Open AccessNew perspectives and future directions in the treatment of heart failure
The management of heart failure has changed significantly over the last 30 years, leading to improvements in the quality of life and outcomes, at least for patients with a substantially reduced left ventricula...
