15 Result(s)

Article

The Hypervariable Tpr Multigene Family of Theileria Parasites, Defined by a Conserved, Membrane-Associated, C-Terminal Domain, Includes Several Copies with Defined Orthology Between Species

Multigene families often play an important role in host-parasite interactions. One of the largest multigene families in Theileria parva, the causative agent of East Coast fever, is the T. parva repeat (Tpr) gene ...

Nicholas C. Palmateer, James B. Munro, Sushma Nagaraj… in Journal of Molecular Evolution (2023)

Article

2022 Zuckerkandl Prize

David A. Liberles, David Alvarez-Ponce, Michelle M. Meyer… in Journal of Molecular Evolution (2023)

Article

STRIDE: a command-line HMM-based identifier and sub-classifier of Plasmodium falciparum RIFIN and STEVOR variant surface antigen families

RIFINs and STEVORs are variant surface antigens expressed by P. falciparum that play roles in severe malaria pathogenesis and immune evasion. These two highly diverse multigene families feature multiple paralogs,...

Albert E. Zhou, Zalak V. Shah, Katie R. Bradwell, James B. Munro… in BMC Bioinformatics (2022)

Article

A genoty** assay to determine geographic origin and transmission potential of Plasmodium falciparum malaria cases

As countries work towards malaria elimination, it is important to monitor imported cases to prevent reestablishment of local transmission. The Plasmodium falciparum Pfs47 gene has strong geographic population str...

Alvaro Molina-Cruz, Nadia Raytselis, Roxanne Withers… in Communications Biology (2021)

Article

Re-annotation of the Theileria parva genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved pathway in many organisms

The apicomplexan parasite Theileria parva causes a livestock disease called East coast fever (ECF), with millions of animals at risk in sub-Saharan East and Southern Africa, the geographic distribution of T. parv...

Kyle Tretina, Roger Pelle, Joshua Orvis, Hanzel T. Gotia, Olukemi O. Ifeonu… in BMC Genomics (2020)

Article

Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva

Theileria parva is an intracellular parasite that causes a lymphoproliferative disease in cattle. It does so by inducing cancer-like phenotypes in the host cells it infects, although t...

Kyle Tretina, Roger Pelle, Joana C. Silva in BMC Genomics (2016)

Article

The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence

There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by...

Martin Norling, Richard P. Bishop, Roger Pelle, Weihong Qi, Sonal Henson… in BMC Genomics (2015)

Article

A Novel Clade of Unique Eukaryotic Ribonucleotide Reductase R2 Subunits is Exclusive to Apicomplexan Parasites

Apicomplexa are protist parasites of tremendous medical and economic importance, causing millions of deaths and billions of dollars in losses each year. Apicomplexan-related diseases may be controlled via inhi...

James B. Munro, Christopher G. Jacob, Joana C. Silva in Journal of Molecular Evolution (2013)

Article

Comparative genomic analysis and phylogenetic position of Theileria equi

Transmission of arthropod-borne apicomplexan parasites that cause disease and result in death or persistent infection represents a major challenge to global human and animal health. First described in 1901 as Pir...

Lowell S Kappmeyer, Mathangi Thiagarajan, David R Herndon, Joshua D Ramsay… in BMC Genomics (2012)

Article

The protist Trichomonas vaginalis harbors multiple lineages of transcriptionally active Mutator-like elements

For three decades the Mutator system was thought to be exclusive of plants, until the first homolog representatives were characterized in fungi and in early-diverging amoebas earlier in this decade.

Fabrício R Lopes, Joana C Silva, Marlene Benchimol, Gustavo GL Costa… in BMC Genomics (2009)

Article

IDEA: Interactive Display for Evolutionary Analyses

The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints and other molecular evolution variables of...

Rain Simons, Anup Mahurkar, Jonathan Crabtree, Jonathan H Badger… in BMC Bioinformatics (2008)

Article

Properties of non-coding DNA and identification of putative cis-regulatory elements in Theileria parva

Parasites in the genus Theileria cause lymphoproliferative diseases in cattle, resulting in enormous socio-economic losses. The availability of the genome sequences and annotation for T. parva and T. annulata has...

**ang Guo, Joana C Silva in BMC Genomics (2008)

Article

Characterization of paralogous protein families in rice

High gene numbers in plant genomes reflect polyploidy and major gene duplication events. Oryza sativa, cultivated rice, is a diploid monocotyledonous species with a ~390 Mb genome that has undergone segmental dup...

Haining Lin, Shu Ouyang, Rain Simons, Kan Nobuta, Brian J Haas… in BMC Plant Biology (2008)

Article

Intron gain and loss in segmentally duplicated genes in rice

Introns are under less selection pressure than exons, and consequently, intronic sequences have a higher rate of gain and loss than exons. In a number of plant species, a large portion of the genome has been s...

Haining Lin, Wei Zhu, Joana C Silva, Xun Gu, C Robin Buell in Genome Biology (2006)