10 Result(s)
within
Joachim Fritzsche
English
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Article
A highly UV-transparent fused silica biochip for sensitive hepatotoxicity testing by autofluorescence
Fabrication and application of a non-fluorescent and UV-transparent microfluidic biochip in fused silica that allows sensitive autofluorescence detection are described. The biochip is particularly useful in ce...
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Article
Open AccessRapid identification of intact bacterial resistance plasmids via optical map** of single DNA molecules
The rapid spread of antibiotic resistance – currently one of the greatest threats to human health according to WHO – is to a large extent enabled by plasmid-mediated horizontal transfer of resistance genes. Ra...
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Article
Open AccessDirect identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA map**
Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA map** of single plasmids in nanofluidic channels, which provide...
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Article
Open AccessCorrection: Corrigendum: Rapid identification of intact bacterial resistance plasmids via optical map** of single DNA molecules
Scientific Reports 6: Article number: 30410; published online: 27 July 2016; updated: 22 December 2017. In the Supplementary Information file originally published with this Article, Figures S8 and S12 were omi...
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Protocol
Fluorescence Microscopy of Nanochannel-Confined DNA
Stretching of DNA in nanoscale confinement allows for several important studies. The genetic contents of the DNA can be visualized on the single DNA molecule level and both the polymer physics of confined DNA ...
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Article
Open AccessA nanofluidic device for parallel single nanoparticle catalysis in solution
Studying single catalyst nanoparticles, during reaction, eliminates averaging effects that are an inherent limitation of ensemble experiments. It enables establishing structure–function correlations beyond ave...
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Article
Open AccessGrain-growth mediated hydrogen sorption kinetics and compensation effect in single Pd nanoparticles
Grains constitute the building blocks of polycrystalline materials and their boundaries determine bulk physical properties like electrical conductivity, diffusivity and ductility. However, the structure and ev...
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Article
Open AccessLabel-free nanofluidic scattering microscopy of size and mass of single diffusing molecules and nanoparticles
Label-free characterization of single biomolecules aims to complement fluorescence microscopy in situations where labeling compromises data interpretation, is technically challenging or even impossible. Howeve...
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Article
Open AccessInverse designed plasmonic metasurface with parts per billion optical hydrogen detection
Plasmonic sensors rely on optical resonances in metal nanoparticles and are typically limited by their broad spectral features. This constraint is particularly taxing for optical hydrogen sensors, in which hyd...
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Protocol
Fluorescence Microscopy of Nanochannel-Confined DNA
Stretching of DNA in nanoscale confinement allows for several important studies. The genetic contents of the DNA can be visualized on the single DNA molecule level, and the polymer physics of confined DNA and ...
