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  1. Article

    Open Access

    Brain structural covariances in the ageing brain in the UK Biobank

    The morphologic properties of brain regions co-vary or correlate with each other. Here we investigated the structural covariances of cortical thickness and subcortical volumes in the ageing brain, along with t...

    Chao Dong, Anbupalam Thalamuthu, Jiyang Jiang in Brain Structure and Function (2024)

  2. No Access

    Article

    Hormonal factors moderate the associations between vascular risk factors and white matter hyperintensities

    To examine the moderation effects of hormonal factors on the associations between vascular risk factors and white matter hyperintensities in men and women, separately. White matter hyperintensities were automa...

    Abdullah Alqarni, Wei Wen, Ben C. P. Lam, John D. Crawford in Brain Imaging and Behavior (2023)

  3. Article

    Open Access

    Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

    Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in...

    Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand in Nature Medicine (2023)

  4. No Access

    Article

    Cognitive decline is associated with frequency-specific resting state functional changes in normal aging

    Resting state low-frequency brain activity may aid in our understanding of the mechanisms of aging-related cognitive decline. Our purpose was to explore the characteristics of the amplitude of low-frequency fl...

    Dongqiong Fan, Tao Liu, Jiyang Jiang, Nicole A. Kochan in Brain Imaging and Behavior (2022)

  5. No Access

    Article

    Genetic variants associated with longitudinal changes in brain structure across the lifespan

    Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we id...

    Rachel M. Brouwer, Marieke Klein, Katrina L. Grasby, Hugo G. Schnack in Nature Neuroscience (2022)

  6. No Access

    Article

    White matter hyperintensities are associated with falls in older people with dementia

    White Matter Hyperintensities (WMHs) are associated with impaired gait, balance and cognition and increased fall risk in cognitively healthy older people. However, few studies have examined such relationships ...

    Morag E. Taylor, Stephen R. Lord, Kim Delbaere, Wei Wen in Brain Imaging and Behavior (2019)