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Article
Open AccessDevelopment of a reverse genetics system for respiratory syncytial virus long strain and an immunogenicity study of the recombinant virus
Respiratory Syncytial Virus (RSV) is an important human respiratory pathogen, particularly of infants and older adults, and despite several decades of research and development, no licensed vaccine is available...
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Article
Open AccessIn situ expression of (R)-carbonyl reductase rebalancing an asymmetric pathway improves stereoconversion efficiency of racemic mixture to (S)-phenyl-1,2-ethanediol in Candida parapsilosis CCTCC M203011
Candida parapsilosis (R)-carbonyl reductase (RCR) and (S)-carbonyl reductase (SCR) are involved in the stereoconversion of racemic (R,S)-1-phenyl-1,2-ethanediol (PED) to its (S)-isomer...
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Chapter and Conference Paper
TeslaML: Steering Machine Learning Automatically in Tencent
In this demonstration, we showcase TeslaML, the machine learning (ML) platform in Tencent Inc. TeslaML offers an interactive and visual workspace for users to create an ML pipeline via dragging, placing, and c...
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Chapter and Conference Paper
StroMAX: Partitioning-Based Scheduler for Real-Time Stream Processing System
With the increasing availability and scale of data from Web 2.0, the ability to efficiently and timely analyze huge amounts of data is important for industry success. A number of real-time stream processing pl...
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Article
Open AccessSortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency
(S)-carbonyl reductase II (SCRII) from Candida parapsilosis is a short-chain alcohol dehydrogenase/reductase. It catalyses the conversion of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol with low efficienc...
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Article
Vimentin Promotes Astrocyte Activation After Chronic Constriction Injury
Vimentin, among the family of the intermediate filament, plays as the organizer of some critical proteins involved in migration, attachment, and cell signaling. In this study, the role of vimentin in chronic c...
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Chapter and Conference Paper
FeatureBand: A Feature Selection Method by Combining Early Stop** and Genetic Local Search
Feature selection is an important problem in machine learning and data mining. In reality, the wrapper methods are broadly used in feature selection. It treats feature selection as a search problem using a pre...
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Chapter and Conference Paper
Sparse Gradient Compression for Distributed SGD
Communication bandwidth is a bottleneck in distributed machine learning, and limits the system scalability. The transmission of gradients often dominates the communication in distributed SGD. One promising tec...
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Article
Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway
Osteoarthritis (OA), which is characterized as a common degenerative joint disease, is presently the most prevalent chronic degenerative joint disease. Accumulating evidence has shown a biological function for Ga...
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Article
Snapshot boosting: a fast ensemble framework for deep neural networks
Boosting has been proven to be effective in improving the generalization of machine learning models in many fields. It is capable of getting high-diversity base learners and getting an accurate ensemble model ...
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Article
Non-horizontal binocular vision ranging method based on pixels
In a conventional stereo vision ranging system, two detectors placed horizontally calculate the distance between the target and the detector based on the triangular similarity principle, parallax and focal len...
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Article
Correction to: Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway
The original version of this article contained mistakes, and the authors would like to correct them.
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Article
Interaction between C/EBPβ and RUNX2 promotes apoptosis of chondrocytes during human lumbar facet joint degeneration
The pathophysiological changes in cartilage are a crucial feature of lumbar facet joint (LFJ) degeneration and arthritis. However, the molecular mechanism of human LFJ degeneration remains largely defined. Thi...
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Article
SKCompress: compressing sparse and nonuniform gradient in distributed machine learning
Distributed machine learning (ML) has been extensively studied to meet the explosive growth of training data. A wide range of machine learning models are trained by a family of first-order optimization algorit...
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Chapter and Conference Paper
NNRW-Based Algorithm Selection for Software Model Checking
Software model checking is the technique that can automatically verify whether a given software meets the correctness properties. Although a large number of software model checkers have been developed, it rema...
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Article
Green Synthesis of Mechanical Robust Superhydrophobic CNT@PU Coatings with High Flexibility for Extensive Applications
Superhydrophobic coatings with high flexibility and mechanical durability can well address many practical application problems. To this end, we proposed and fabricated a kind of bio-based superhydrophobic (mul...
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Article
Sprouty2 Inhibits Migration and Invasion of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Down-regulating ATF2 Expression and Phosphorylation
Activating transcription factor 2(ATF2), a transcription factor belonging to the AP-1 family, plays an important role in inflammation. However, its biological functions and underlying molecular mechanisms in r...
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Article
Knockdown of TRAF6 inhibits chondrocytes apoptosis and inflammation by suppressing the NF-κB pathway in lumbar facet joint osteoarthritis
Tumor necrosis factor receptor-associated factor 6 (TRAF6), a regulator of NF-κB signaling, has been discovered recently to be probably related to osteoarthritis, while the function of TRAF6 in lumbar facet jo...
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Article
On-Orbit Performance of the FY-4 GIIRS Stirling Cryocooler Over 2 Years
The Fengyun series 4 (FY-4) Geostationary Interferometric Infrared Sounder (GIIRS) is the first interferometric infrared sounder operating in geostationary orbit internationally, for vertical air soundings of ...
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Article
Model averaging in distributed machine learning: a case study with Apache Spark
The increasing popularity of Apache Spark has attracted many users to put their data into its ecosystem. On the other hand, it has been witnessed in the literature that Spark is slow when it comes to distribut...
