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Article
The association between non-HDL cholesterol and high-grade pancreatic neuroendocrine neoplasms
High-density lipoprotein cholesterol (HDL-c) plays an important role in tumorigenesis in several endocrine-related cancers. Few studies have shown the effect of non-HDL-c in malignant tumors. The present study...
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Article
Open AccessGenome mining shows that retroviruses are pervasively invading vertebrate genomes
Endogenous retroviruses (ERVs) record past retroviral infections, providing molecular archives for interrogating the evolution of retroviruses and retrovirus-host interaction. However, the vast majority of ERV...
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Article
Open AccessSpatial–temporal variation of extreme precipitation in the Yellow–Huai–Hai–Yangtze Basin of China
Climate warming leads to frequent extreme precipitation events, which is a prominent manifestation of the variation of the global water cycle. In this study, data from 1842 meteorological stations in the Huang...
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Article
Open AccessAn autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin loo**
Genetic sharing is extensively observed for autoimmune diseases, but the causal variants and their underlying molecular mechanisms remain largely unknown. Through systematic investigation of autoimmune disease...
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Article
The oldest gnathostome teeth
Mandibular teeth and dentitions are features of jawed vertebrates that were first acquired by the Palaeozoic ancestors1–3 of living chondrichthyans and osteichthyans. The fossil record currently points to the lat...
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Article
The oldest complete jawed vertebrates from the early Silurian of China
Molecular studies suggest that the origin of jawed vertebrates was no later than the Late Ordovician period (around 450 million years ago (Ma))1,2. Together with disarticulated micro-remains of putative chondrich...
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Article
Spiny chondrichthyan from the lower Silurian of South China
Modern representatives of chondrichthyans (cartilaginous fishes) and osteichthyans (bony fishes and tetrapods) have contrasting skeletal anatomies and developmental trajectories1–4 that underscore the distant evo...
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Article
Open AccessAnalysis of mutations in DNA damage repair pathway gene in Chinese patients with hepatocellular carcinoma
The incidence of hepatocellular carcinoma (HCC) has increased in these years. DNA damage repair (DDR) pathway is required in response to DNA damage Gene mutations in DDR pathway play an important role in diffe...
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Article
Open AccessA new model based inflammatory index and tumor burden score (TBS) to predict the recurrence of hepatocellular carcinoma (HCC) after liver resection
To establish a model based on inflammation index and tumor burden score (TBS) to predict recurrence of hepatocellular carcinoma (HCC) after liver resection. A retrospective study was performed on 217 patients ...
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Article
Open AccessTranscriptomic profiling of the high-vigour maize (Zea mays L.) hybrid variety response to cold and drought stresses during seed germination
Abiotic stresses, including cold and drought, negatively affect maize (Zea mays L.) seed field emergence and later yield and quality. In order to reveal the molecular mechanism of maize seed resistance to abiotic...
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Article
Open AccessInterval uncertainty analysis of a confined aquifer
Water inflow forecast is influenced by many factors and yields uncertain results. To more accurately predict the magnitude of water inflow and quantitatively define the corresponding response in the parameter ...
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Article
Open Access3-D shape reconstruction of non-uniform reflectance surface based on pixel intensity, pixel color and camera exposure time adaptive adjustment
High dynamic range 3-D shape measurement is a challenge. In this work, we propose a novel method to solve the 3-D shape reconstruction of high-reflection and colored surfaces. First, we propose a method to est...
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Article
Open AccessLong Noncoding RNA CTC Inhibits Proliferation and Invasion by Targeting miR-146 to Regulate KIT in Papillary Thyroid Carcinoma
Several lines of evidence have shown that long non-coding RNAs (lncRNAs) are dysregulated in many diseases. Nevertheless, the biological relevance of the lncRNAs in papillary thyroid carcinoma (PTC) has not be...
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Article
Open AccessAll-fiber continuous-wave Raman fiber oscillator operating at 2118 nm
An all-fiber Raman fiber oscillator operating at 2118 nm pumped by homemade thulium-doped fiber laser with continuous output power of 4.2 W has been demonstrated in this paper. By means of 26 m ultrahigh-numer...
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Article
Reply to: Evidence for two blue (type IIb) diamond populations
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Open AccessInternalization, distribution, and activity of peptide H2 against the intracellular multidrug-resistant bovine mastitis-causing bacterium Staphylococcus aureus
Bovine mastitis is mainly caused by Staphylococcus aureus, which is difficult to eliminate, prone to escape from antibacterial agents, and may cause recurring infections due to the intracellular nature of its inf...
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Open AccessImprovement of dielectric performance of solid/gas composite insulation with YSZ/ZTA coatings
N2 has been introduced to gas-insulated switchgears (GIS) as an environmentally friendly insulation medium for SF6 gas. Considering the low breakdown strength of N2, it’s essential to apply a dielectric coating o...
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Article
Author Correction: Structure and mechanogating mechanism of the Piezo1 channel
In Extended Data Fig. 9a of this Article, the bottom micrographs of mPiezo1-ΔL3-4-IRES-GFP and mPiezo1-ΔL7-8-IRES-GFP (labelled ‘permeabilized’) are inadvertently the same images. The corrected figure panels a...
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Article
Distribution of metabolic/obese phenotypes and association with diabetes: 5 years’ cohort based on 22,276 elderly
To describe the distribution and changes of different metabolic/obese phenotypes among more than 22,000 male elderly in China, and also explore the association with diabetes incidence.
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Article
Open AccessInduction chemotherapy followed by concurrent chemoradiotherapy is benefit for advanced stage nasopharyngeal carcinoma with different nonkeratinizing carcinoma subtypes
Given the potentially distinctive histological variations in northwest of China, the aim of current study was to compare the efficacy of induction chemotherapy plus concurrent chemoradiotherapy (IC + CCRT) wit...