30 Result(s)

Article

Pharmacokinetics and pharmacodynamics of antibacterial peptide NZX in Staphylococcus aureus mastitis mouse model

Staphylococcus aureus is associated with dairy mastitis, which causes serious economic losses to dairy farming industry. Antibacterial peptide NZX showed good antibacterial activity against S. aureus. This study ...

Xueling Zheng, Na Yang, Ruoyu Mao, Ya Hao… in Applied Microbiology and Biotechnology (2024)

Article

Expression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus

The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. The improvement of activity and yield through modification and heterologous expression, a potential way to solve the problem, ...

Kun Zhang, Na Yang, Da Teng, Ruoyu Mao, Ya Hao… in Applied Microbiology and Biotechnology (2024)

Article

A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli

Pathogenic Escherichia coli is one of the most common causes of diarrhea diseases and its characteristic component of the outer membrane-lipopolysaccharide (LPS) is a major inducer of sepsis. Few drugs have been ...

Zhenlong Wang, Da Teng, Ruoyu Mao, Ya Hao, Na Yang, **umin Wang… in Communications Biology (2023)

Article

Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears

Muscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic progenitors (FAPs). Compared to the RCT, fatty infiltration is not s...

**ngzuan Lin, Peng Wang, Wei Wang, Hao Zhou, Siyuan Zhu… in Cell Death Discovery (2023)

Article

Lactoferrin, a Great Wall of host-defence?

Jianhua Wang, Na Yang, Hans J. Vogel in BioMetals (2023)

Article

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...

Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang… in Cell Death & Disease (2022)

Article

A model for genuineness detection in genetically and phenotypically similar maize variety seeds based on hyperspectral imaging and machine learning

Variety genuineness and purity are essential indices of maize seed quality that affect yield. However, detection methods for variety genuineness are time-consuming, expensive, require extensive training, or de...

Keling Tu, Shaozhe Wen, Ying Cheng, Yanan Xu, Tong Pan, Haonan Hou… in Plant Methods (2022)

Article

C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo

Enteropathogenic Escherichia coli and Salmonella pullorum are two important groups of zoonotic pathogens. At present, the treatment of intestinal pathogenic bacteria infection mainly relies on antibiotics, which ...

Ting Li, Na Yang, Da Teng, Ruoyu Mao, Ya Hao, **umin Wang, Jianhua Wang in BMC Microbiology (2022)

Article

Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women

Ovarian cancer survival varies considerably among patients, to which germline variation may also contribute in addition to mutational signatures. To identify genetic markers modulating ovarian cancer outcome, ...

Hongji Dai, **nlei Chu, Qian Liang, Mengyun Wang, Lian Li, Yao Zhou… in Cell Discovery (2021)

Article

Seed biostimulant Bacillus sp. MGW9 improves the salt tolerance of maize during seed germination

Crop performance is seriously affected by high salt concentrations in soils. To develop improved seed pre-sowing treatment technologies, it is crucial to improve the salt tolerance of seed germination. Here, w...

Heqin Li, Haiwang Yue, Li Li, Yu Liu, Haiyan Zhang, Jianhua Wang… in AMB Express (2021)

Article

Pedigree-based genetic dissection of quantitative loci for seed quality and yield characters in improved soybean

As soybean plays an indispensable role in the supply of vegetable oil and protein, balancing the relationship between seed quality and yield traits according to human demand has become an important breeding go...

Wenxuan Huang, **g**g Hou, Quan Hu, Jie An, Yanwei Zhang, Qi Han… in Molecular Breeding (2021)

Article

Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration

Necroptosis, a form of programmed cell death, is characterized by the loss of membrane integrity and release of intracellular contents, the execution of which depends on the membrane-disrupting activity of the...

Shen’ao Zhou, Wei Zhang, Gaihong Cai, Yingzhe Ding, Caixia Wei, Sheng Li… in Cell Research (2020)

Article

LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression

The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows th...

Mengfei Yao, **aolei Shi, Yue Li, Yutian **ao, William Butler… in Cell Death & Disease (2020)

Article

Therapeutic potential of a designed CSαβ peptide ID13 in Staphylococcus aureus-induced endometritis of mice

Staphylococcus aureus is a common pathogen that can cause clinical and subclinical endometritis in humans and animals. In this study, a designed CSαβ peptide ID13 from DLP4 exhibited high stable antibacterial act...

Bing Li, Na Yang, Yuxue Shan, **umin Wang, Ya Hao… in Applied Microbiology and Biotechnology (2020)

Article

The effect of ursodeoxycholic acid on the relative expression of the lipid metabolism genes in mouse cholesterol gallstone models

Many studies indicate that gallstone formation has genetic components. The abnormal expression of lipid-related genes could be the basis for particular forms of cholesterol gallstone disease. The aim of this s...

Ning Fan, Ke Meng, Yuqing Zhang, Yong Hu, Donghua Li… in Lipids in Health and Disease (2020)

Article

Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli

Pathogenic Escherichia coli can cause fatal diarrheal diseases in both animals and humans. However, no antibiotics or antimicrobial peptides (AMPs) can adequately kill resistant bacteria and clear bacterial endot...

Zhenlong Wang, Xuehui Liu, Da Teng, Ruoyu Mao, Ya Hao, Na Yang… in Communications Biology (2020)

Article

Antiviral effects of ferric ammonium citrate

Iron is an essential nutrient for cell survival and is crucial for DNA replication, mitochondrial function and erythropoiesis. However, the immunological role of iron in viral infections has not been well defi...

Hongbin Wang, Zheng Li, Junling Niu, Yongfen Xu, Li Ma, Ailing Lu… in Cell Discovery (2018)

Article

Escherichia coli outer membrane protein F (OmpF): an immunogenic protein induces cross-reactive antibodies against Escherichia coli and Shigella

Diarrhea caused by pathogenic Escherichia coli (E. coli) is one of the most serious infectious diseases in humans and animals. Due to antibiotics resistance and the lack of efficient vaccine, more attention shoul...

**ao Wang, Da Teng, Qingfeng Guan, Ruoyu Mao, Ya Hao, **umin Wang, Junhu Yao… in AMB Express (2017)

Article

Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of H...

Huixian Chen, Ruoyu Mao, Da Teng, **umin Wang, Ya Hao, **ngjun Feng… in AMB Express (2017)

Article

In vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models

NZ2114 is a promising candidate for therapeutic application owing to potent activity to gram-positive bacterium such as Streptococcus pneumoniae and Staphylococcus aureus. This work is the first report to describ...

Jian Jiao, Ruoyu Mao, Da Teng, **umin Wang, Ya Hao, Na Yang, **ao Wang… in AMB Express (2017)