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Protocol
Multisite Optical Measurement of Membrane Potential
An optical measurement of membrane potential using a molecular probe might be beneficial in a variety of circumstances. “Such a probe could, we believe, provide a powerful new technique for measuring membrane ...
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Article
One neuron, many units?
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Article
Voltage-sensitive dyes for monitoring multineuronal activity in the intact central nervous system
Optical monitoring of activity provides new kinds of information about brain function. Two examples are discussed in this article. First, the spike activity of many individual neurons in small ganglia can be d...
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Article
Open AccessDynamical evolution of spatiotemporal patterns in mammalian middle cortex
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Chapter
In Vivo Dynamics of the Visual Cortex Measured with Voltage Sensitive Dyes
Voltage sensitive dye (VSD) imaging is an optical method for measuring trans-membrane potentials. This method has developed into a powerful tool for studying brain dynamics. VSD molecules bind to the membranes...
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Chapter
Monitoring Population Membrane Potential Signals from Neocortex
Voltage-sensitive dyes (VSDs) and optical imaging are useful tools for studying spatiotemporal patterns of population neuronal activity in cortical tissue. Using a photodiode array and absorption dyes, we are ...
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Chapter
Monitoring Population Membrane Potential Signals from Neocortex
Voltage-sensitive dyes (VSDs) and optical imaging are useful tools for studying spatiotemporal patterns of population neuronal activity in cortex. Because fast VSDs respond to membrane potential changes with m...
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Article
Open AccessHigh-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
Repeated head impact exposure can cause memory and behavioral impairments. Here, we report that exposure to non-damaging, but high frequency, head impacts can alter brain function in mice through synaptic adap...
