9,998 Result(s)
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Article
Early morphologic changes in coronary arteries of experimental diabetic rats
Diabetes was induced in 24 adult male Wistar rats by a single intravenous injection of streptozotocin. The ultramorphology of the coronary arterial wall was studied by scanning and transmission electron micros...
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Article
Pancreatic exocrine enzymes during the neonatal period in postmature rats
Pancreatic content of exocrine enzymes in newborn rat pups shows a sharp decline soon after birth. To investigate if this decline is a preprogrammed and, therefore, inherently controlled phenomenon, or a resul...
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A research for the relationship between human papillomavirus and human uterine cervical carcinoma
Biopsies from 318 cases with squamous cell carcinoma of the uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 with nor...
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Chapter
Significant Species Differences in Local IGF-I and -II Gene Expression
Much thinking about the roles of IGF-I and -II is shaped by observations in the rat or mouse, although it is not clear to what extent these laboratory rodents reflect IGF system function or regulation in other...
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The role of cryosurgery in the treatment of hepatic cancer: a report of 113 cases
From November 1973 to June 1992, cryosurgery with liquid nitrogen (−196°C) was performed on 113 patients with hepatic cancer, including 107 patients with primary liver cancer (PLC) and 6 patients with secondar...
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Chapter
Androgen Regulation of Ocular Mucosal- and Auto-Immunity
At present, it is known that androgens exert a tremendous impact on the development, expression and function of the immune system in both health and disease. In brief, these hormones have been shown to: [a] in...
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Article
Recovery of antitumor CD4+ T cell responsiveness, suppressed in the tumor-bearing state, by release from tumor burden
The present study investigates the recovery of antitumor CD4+ T cell responsiveness, suppressed in the tumor-bearing state, following release of tumor burden. Spleen cells from BALB/c mice bearing a syngeneic tum...
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Neural, Endocrine and Immune Regulation of Secretory Component Production by Lacrimal Gland Acinar Cells
Our previous research has shown that the endocrine, nervous and immune systems regulate the production of secretory component (SC), the polymeric immunoglobulin receptor, by acinar (epithelial) cells from the ...
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Basic Biology of Pig Fetal Pancreas and Its Use as an Allograft
Diabetes is a chronic disorder of metabolism, which has the potential to result in the development of microvascular complications, such as retinopathy and nephropathy, many years after the onset of the disease...
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Article
Treatment of human hepatocellular carcinoma by fibroblast-mediated human interferon α gene therapy in combination with adoptive chemoimmunotherapy
The therapeutic effect of the fibroblast-mediated human interferon (IFNα) gene therapy in combination with interleukin-2 (IL-2) activated killer cells (AK)/doxorubicin (i.e., adoptive chemoimmunotherapy) on nu...
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Article
Specificity of simple hormone response elements in androgen regulated genes
Androgen (AR) and glucocorticoid (GR) receptors recognize a family of 15 base pair partial palindromic hormone response elements (HRE). We have studied receptor interactions with several HREs from androgen reg...
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Article
mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential
Levels of expression of the nm23 gene inversely correlated with metastatic potential in several rodent tumor model systems and human breast carcinoma. In the present study, we examined nm23 mRNA levels in two ...
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Article
Human hepatitis B virus and hepatocellular carcinoma II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1
On the basis of the successful establishment of an animal model in tree shrews experimentally infected with human hepatitis B virus (HBV), a study on the hepatocarcinogenic effects of HBV and/or aflatoxin B1 (...
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Human hepatitis B virus and hepatocellular carcinoma I. Experimental infection of tree shrews with hepatitis B virus
Tree shrews (Tupaia belangeri chinenesis) can be experimentally infected with human hepatitis B virus (HBV) by inoculation with human serum positive for HBV, the experimental infection rate being 55.21%. Successi...
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Article
Regulation of glucagon-like peptide-I receptor expression and transcription by the protein kinase C pathway
Glucagon-like peptide-I (GLP-I) is an important insulinotropic incretin hormone. The GLP-I receptor belongs to the family of seven transmembrane domain receptors. We studied the regulation of its expression by...
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Article
Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-β
Interferons inhibit cell growth in normal and tumor-derived cells. The molecular basis of interferons antiproliferative activity remains to be defined. Using subtraction hybridization, a human melanoma differe...
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Article
Allogeneic peripheral blood stem cell transplantation in the treatment of leukemia in China
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Article
Functional roles of E2F in cell cycle regulation
The E2F family of transcription factors play a key role in G1-S progression. A dominant negative mutant (E2F97) of E2F1 containing the DNA binding domain of E2F1 under the control of a tetracycline-responsive ...
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Article
The retinoblastoma gene family is differentially expressed during embryogenesis
We report differential expression of the RB1 tumor suppressor gene and the homologous genes p107 and p130 during embryogenesis. Abundant RB1 transcripts were detected during neurogenesis, hematopoiesis, myogenesi...
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Article
Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60)
The p21MDA6 gene product induces cell cycle arrest in p53-null human leukemic cells exposed to differentiation stimuli. We employed an HL-60 cell line stably transfected with a p21MDA6 antisense construct to comp...
