41 Result(s)
-
Article
Open AccessInbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG
Isoniazid (INH), an anti-tuberculosis (TB) drug, has been widely used for nearly 60 years. However, the pathway through which Mycobacterium tuberculosis responds INH remain largely unclear. In this study, we char...
-
Article
Open AccessAstroglial β-Arrestin1-mediated Nuclear Signaling Regulates the Expansion of Neural Precursor Cells in Adult Hippocampus
Adult hippocampal neurogenesis is crucial for preserving normal brain function, but how it is regulated by niche cells is uncertain. Here we show that β-arrestin 1 (β-arr1) in dentate gyrus (DG) regulates neur...
-
Article
Open AccessConformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation
Helix α9 of Bax protein can dimerize in the mitochondrial outer membrane (MOM) and lead to apoptotic pores. However, it remains unclear how different conformations of the dimer contribute to the pore formation...
-
Article
Open AccessThe RhoA/ROCK Pathway Ameliorates Adhesion and Inflammatory Infiltration Induced by AGEs in Glomerular Endothelial Cells
A recent study demonstrated that advanced glycation end products (AGEs) play a role in monocyte infiltration in mesangial areas in diabetic nephropathy. The Ras homolog gene family, member A Rho kinase (RhoA/R...
-
Article
Open AccessEffects of hydrological regime on development of Carex wet meadows in East Dongting Lake, a Ramsar Wetland for wintering waterbirds
Wet meadows are one of the most important ecological components in floodplain, and are among the most dynamic ecosystems. Understanding the development of wet meadows and contributing environmental factors can...
-
Article
Open AccessA data-driven approach for evaluating multi-modal therapy in traumatic brain injury
Combination therapies targeting multiple recovery mechanisms have the potential for additive or synergistic effects, but experimental design and analyses of multimodal therapeutic trials are challenging. To ad...
-
Article
Open AccessNuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy
Beclin 1 is a well-established core mammalian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show that Beclin ...
-
Article
Open AccessQuantitative assessment of liver fibrosis (qFibrosis) reveals precise outcomes in Ishak “stable” patients on anti-HBV therapy
Current widely used semiquantitative histological assessment methods are insensitive to identify subtle changes of liver fibrosis. Therefore, to precisely assess therapeutic efficacy on chronic hepatitis B (CH...
-
Article
Open AccessStructure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component
Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae su...
-
Article
Open AccessEnantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
Transition-metal-catalyzed cycloisomerization of 1,n-allenynes represents a powerful synthetic tool to rapidly assemble complex polycyclic skeletons from simple linear substrates. Nevertheless, there are no re...
-
Article
Open AccessMiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer
MiR-494 plays an important role in several types of human cancers, including non-small cell lung cancer (NSCLC). Although the role of miR-494 has been investigated in several studies, the expression profile an...
-
Article
Open AccessAuthor Correction: Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
-
Article
Open AccessThermal damage in three-dimensional vivo bio-tissues induced by moving heat sources in laser therapy
The thermal damage of a three-dimensional bio-tissue model irradiated by a movable laser beam was studied in this work. By employing the DPL biological heat conduction model and Henriques’ thermal damage asses...
-
Article
Open AccessGenome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common. By using genome-wide CRISPR/Cas9 library screening, we identify phosphogl...
-
Article
Open AccessMolecular Imaging of Endometriosis Tissues using Desorption Electrospray Ionization Mass Spectrometry
Endometriosis is a pathologic condition affecting approximately 10% of women in their reproductive years. Characterized by abnormal growth of uterine endometrial tissue in other body areas, endometriosis can c...
-
Article
Open AccessUnusual KIE and dynamics effects in the Fe-catalyzed hetero-Diels-Alder reaction of unactivated aldehydes and dienes
Hetero-Diels-Alder (HDA) reaction is an important synthetic method for many natural products. An iron(III) catalyst was developed to catalyze the challenging HDA reaction of unactivated aldehydes and dienes wi...
-
Article
Open AccessThe outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. The presence of aggressive pathologic risk factors foll...
-
Article
Open AccessConnecting glass-forming ability of binary mixtures of soft particles to equilibrium melting temperatures
The glass-forming ability is an important material property for manufacturing glasses and understanding the long-standing glass transition problem. Because of the nonequilibrium nature, it is difficult to deve...
-
Article
Open AccessExpanded encyclopaedias of DNA elements in the human and mouse genomes
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the ...
-
Article
Open AccessBio-heat response of skin tissue based on three-phase-lag model
In this article, the thermal response of skin tissue is investigated based on three-phase-lag (TPL) model of heat conduction. The governing equation of bio-heat conduction is established by introducing both th...
