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  1. Article

    Open Access

    Systematic functional interrogation of human pseudogenes using CRISPRi

    The human genome encodes over 14,000 pseudogenes that are evolutionary relics of protein-coding genes and commonly considered as nonfunctional. Emerging evidence suggests that some pseudogenes may exert import...

    Ming Sun, Yunfei Wang, Caishang Zheng, Yanjun Wei, Jiakai Hou, Peng Zhang… in Genome Biology (2021)

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    Article

    LIMITing tumours with an immunogenic lncRNA

    Overcoming immune resistance mechanisms in patients with cancer is critical for successful immunotherapy. A new study now identifies LIMIT as an immunogenic long non-coding RNA (lncRNA) that intrinsically regu...

    Jiakai Hou, Weiyi Peng in Nature Cell Biology (2021)