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Article
Identification of Protein–Protein Interaction Associated Functions Based on Gene Ontology
Protein–protein interactions (PPIs) involve the physical or functional contact between two or more proteins. Generally, proteins that can interact with each other always have special relationships. Some previo...
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Article
Open AccessTCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling
Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinfo...
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Article
Open AccessAutophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation
Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles and contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability to self-renew,...
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Article
GSA: a GPU-accelerated structure similarity algorithm and its application in progressive virtual screening
A new algorithm is proposed for accelerating chemical structure similarity search by means of graphic processing unit technology. Experiments demonstrate that the new algorithm is on average more than 120-time...