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Open AccessDevelopment and validation of a neoadjuvant chemotherapy pathological complete remission model based on Reg IV expression in breast cancer tissues: a clinical retrospective study
To develop and authenticate a neoadjuvant chemotherapy (NACT) pathological complete remission (pCR) model based on the expression of Reg IV within breast cancer tissues with the objective to provide clinical g...
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Article
Open AccessRelationship between childhood trauma and non-suicidal self-injury in high school students: the mediating role of the stress perception and the moderating role of teacher-student relationship
This study delves into the correlation between childhood trauma and non-suicidal self-injury (NSSI) behaviors among high school students. Additionally, it examines the mediating role of stress perception and t...
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Article
Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Article
Open AccessA MYB-related transcription factor ZmMYBR29 is involved in grain filling
The endosperm serves as the primary source of nutrients for maize (Zea mays L.) kernel embryo development and germination. Positioned at the base of the endosperm, the transfer cells (TCs) of the basal endosperm ...
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Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Article
Effect of Sc on Al3Fe phase and mechanical properties of as-cast AA5052 aluminum alloy
The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing, and with the development of light-weight alloys, it is required that these materials exhibit better mechanical properties. Pr...
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Article
Open AccessCorrection: Development and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
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Open AccessDevelopment and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
This study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative hematoxylin and eosin (HE) stained slides to predict the pathological s...
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Article
Open AccessArnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells
Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...
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Article
Open AccessRGA1 regulates grain size, rice quality and seed germination in the small and round grain mutant srg5
Generating elite rice varieties with high yield and superior quality is the main goal of rice breeding programs. Key agronomic traits, including grain size and seed germination characteristics, affect the fina...
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Open AccessGenome-wide identification, stress- and hormone-responsive expression characteristics, and regulatory pattern analysis of Scutellaria baicalensis SbSPLs
SQUAMOSA PROMOTER BINDING PROTEIN-LIKEs (SPLs) encode plant-specific transcription factors that regulate plant growth and development, stress response, and metabolite accumulation. However, there is limited infor...
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Article
Open AccessAge-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis
Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline...
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Article
Open AccessMiddle-aged and older people’s preference for medical-elderly care integrated institutions in China: a discrete choice experiment study
With the continuing impact of the aging population, medical-elderly care integrated institutions, as a way to bear the pressure of medical and elderly care, effectively ensure the quality of life of the elderl...
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Article
Open AccessUsing signal-to-cutoff ratios of HIV screening assay to predict HIV infection
The sensitivity of HIV screening assays often leads to a high rate of false-positive results, requiring retests and confirmatory tests. This study aimed to analyze the capability of signal-to-cutoff (S/CO) rat...
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Article
Open AccessClinical features, genomic profiling, and outcomes of adult patients with unifocal Langerhans cell histiocytosis
Langerhans cell histiocytosis (LCH) is a rare highly heterogeneous histiocytosis, which can be divided into single system and multiple system disease according to site of involvement. There is a paucity of stu...
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Open AccessRisk prediction of second primary malignancies in patients after rectal cancer: analysis based on SEER Program
This study will focus on exploring the clinical characteristics of rectal cancer (RC) patients with Second Primary Malignancies (SPMs) and constructing a prognostic nomogram to provide clinical treatment decis...
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Article
Open AccessThe anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation
Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as...
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Article
Open AccessExpression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study
Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs ...
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Using standardized uptake values in pyrophosphate imaging
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Open AccessFloral nectar reabsorption and a sugar concentration gradient in two long-spurred Habenaria species (Orchidaceae)
Floral nectar is the most common reward flowers offered to pollinators. The quality and quantity of nectar produced by a plant species provide a key to understanding its interactions with pollinators and predi...
