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Article
Open AccessDevelopment and validation of a neoadjuvant chemotherapy pathological complete remission model based on Reg IV expression in breast cancer tissues: a clinical retrospective study
To develop and authenticate a neoadjuvant chemotherapy (NACT) pathological complete remission (pCR) model based on the expression of Reg IV within breast cancer tissues with the objective to provide clinical g...
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Article
Open AccessRelationship between childhood trauma and non-suicidal self-injury in high school students: the mediating role of the stress perception and the moderating role of teacher-student relationship
This study delves into the correlation between childhood trauma and non-suicidal self-injury (NSSI) behaviors among high school students. Additionally, it examines the mediating role of stress perception and t...
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Article
Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Article
Leveraging single-case results to Bayesian hierarchical modelling
In scientific research, we often aim to learn one or more parameters of instances(objects) from a population—such as the batting averages of a group of baseball players and characteristics of white dwarfs from...
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Article
Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels
Recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for mammalian survival and adaptation to a changing environment. Soci...
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Article
Open AccessA MYB-related transcription factor ZmMYBR29 is involved in grain filling
The endosperm serves as the primary source of nutrients for maize (Zea mays L.) kernel embryo development and germination. Positioned at the base of the endosperm, the transfer cells (TCs) of the basal endosperm ...
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Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Article
Effect of Sc on Al3Fe phase and mechanical properties of as-cast AA5052 aluminum alloy
The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing, and with the development of light-weight alloys, it is required that these materials exhibit better mechanical properties. Pr...
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Article
Overtop** Failure Process and Core Wall Fracture Mechanism of a New Concrete Core Wall Dam
Concrete core wall dams have emerged as a cost-effective alternative to the reconstruction of old dams. However, the flooding mechanism and flood line of these dams differ significantly from traditional earth ...
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Article
A Quantum Image Encryption and Watermarking Algorithm Based on QDCT and Baker map
In many situations, the dual protection of image information transmission security and identity authentication is required. A quantum encryption and watermarking technique combining quantum Baker map (QBM) and...
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Article
A quantitative optimization method for rockfall passive nets on high-steep slopes: case study of the Feishuiyan slope
Rockfall poses a formidable threat to the ongoing fast-paced construction of large-scale projects in uninhabited areas in high mountain valleys. In this study, an optimization method for arranging passive nets...
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Article
Open AccessCorrection: Development and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
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Article
Gravitational Failure Occurrence and Evolution of Rock Slopes Due to Dam Construction: A Case Study of Three Reservoirs in Southwest China
The spatial distribution pattern, DSGSD characteristics and influence of the controlling factors of reservoir rock landslides were analyzed in Southwest China.
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Article
Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method
In the context of global warming and intensified human activities, glacier instability in plateau regions has increased, and glacier debris flows have become active, which poses a significant threat to the liv...
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Article
Utilizing Machine Learning to Identify Biomarkers of Endoplasmic Reticulum Stress and Analyze Immune Cell Infiltration in Parkinson’s Disease
The neurodegenerative disorder known as Parkinson’s disease (PD) affects many people. The objective of this investigation was to examine the relationship between immune system infiltration, ATP-binding cassett...
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Open AccessDevelopment and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
This study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative hematoxylin and eosin (HE) stained slides to predict the pathological s...
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Article
Open AccessArnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells
Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...
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Article
Open AccessRGA1 regulates grain size, rice quality and seed germination in the small and round grain mutant srg5
Generating elite rice varieties with high yield and superior quality is the main goal of rice breeding programs. Key agronomic traits, including grain size and seed germination characteristics, affect the fina...
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Article
A Method for Automatic Assessment of Rockfall Susceptibility Based on High-Resolution Point Clouds
Typical rockfall analysis requires detailed discontinuity measurements; however, the use of conventional contact approaches can be challenging on cliffs. In this study, a novel automatic method for rockfall su...
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Article
Automatic discontinuity identification and quantitative monitoring of unstable blocks using terrestrial laser scanning in large landslide during emergency disposal
Fast and accurate assessment of slope topography and geological information and understanding of slope deformation evolution are of great significance in emergency investigation and monitoring of landslides. I...
