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Transferrin receptor 1 promotes hepatocellular carcinoma progression and metastasis by activating the mTOR signaling pathway

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  1. Article

    Open Access

    A novel murine model of combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma

    Primary liver cancer (PLC) is a common gastrointestinal malignancy worldwide. While hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two major pathologic types of PLC, combined HCC ...

    Ru-Chen Xu, Fu Wang, Jia-Lei Sun, Weinire Abuduwaili… in Journal of Translational Medicine (2022)

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  2. Article

    Open Access

    Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

    Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...

    Jia-Lei Sun, Ning-** Zhang, Ru-Chen Xu… in Journal of Translational Medicine (2021)

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