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Open AccessA RsrC-RsrA-RsrB transcriptional circuit positively regulates polysaccharide-degrading enzyme biosynthesis and development in Penicillium oxalicum
Filamentous fungi produce polysaccharide-degrading enzymes, which is controlled by poorly understood transcriptional circuits. Here we show that a circuit comprising RsrC-RsrA-RsrB (Rsr: production of raw-starch-...
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Article
Overexpression of the MiAGL1 gene from mango promoted flowering in transgenic Arabidopsis
MADS-box genes play a vital role in the vegetative and reproductive growth of plants. In this study, a MiAGL1 gene was cloned and identified from mango (Mangifera indica L.). The DNA sequence of AGAMOUS-LIKE1 (Mi...
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Article
Halide perovskite-based heterostructures for photocatalytic CO2 conversion
Photocatalytic conversion of solar light into chemical fuels represents an appealing pathway by which a sustainable energy future might be realized. However, great scientific challenges need to be addressed fo...
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Article
Open AccessPromotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2
Lung cancer stands as the leading cause of mortality among all types of tumors, with over 40% of cases being lung adenocarcinoma (LUAD). Family with sequence similarity 83 member A (FAM83A) emerges as a notabl...
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Article
A multifactorial screening model based on the Graves ophthalmopathy quality of life scores in dysthyroid optic neuropathy
To validate the Graves ophthalmopathy quality of life (GO-QOL) questionnaire in screening DON and to construct an effective model.
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Article
Application of optimized random forest regressors in predicting the maximum principal stress of aseismic tunnel lining
Using flexible dam** technology to improve tunnel lining structure is an emerging method to resist earthquake disasters, and several methods have been explored to predict mechanical response of tunnel lining...
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Article
Security of quantum key distribution with virtual mutually unbiased bases
In a perfect quantum key distribution (QKD) protocol, quantum states should be prepared and measured with mutually unbiased bases (MUBs). However, in a practical QKD system, quantum states are generally prepar...
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Article
Open AccessCorrection: Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
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Open AccessThe effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system
Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, which render them susceptible to the infiltration of pathogenic factors. LJC, which has a long history i...
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Open AccessIdebenone Antagonizes P53-Mediated Neuronal Oxidative Stress Injury by Regulating CD38-SIRT3 Protein Level
Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD...
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Article
Open AccessMolecular docking and MD simulation studies of 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivatives as novel inhibitors targeted to CDK2/4/6
Nowadays, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have been approved for treating metastatic breast cancer and have achieved inspiring curative effects. But some discoveries have indicated that CDK 4/6...
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Article
A Simplified single-phase neutral-clamped H-bridge cascade converter FCS-MPC control
In order to solve the problem that the computation of single-phase neutral point clamped H-bridge cascade inverter increases exponentially with the number of levels, and the traditional finite control set mode...
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Article
Open AccessAssociation of insomnia symptoms and trajectories with the risk of functional disability: a prospective cohort study
There is limited understanding regarding prospective associations of insomnia symptoms and trajectories with functional disability. We aimed to investigate the associations of insomnia symptoms and trajectorie...
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Article
Open AccessComparison of manual and artificial intelligence-automated choroidal thickness segmentation of optical coherence tomography imaging in myopic adults
Myopia affects 1.4 billion individuals worldwide. Notably, there is increasing evidence that choroidal thickness plays an important role in myopia and risk of develo** myopia-related conditions. With the adv...
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Article
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
Glucose not only provides energy for tumor cells, but also provides various biomolecules that are essential for their survival, proliferation and invasion. Therefore, it is of great clinical significance to un...
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Article
Open AccessQuantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities
HER2-positive (HER2+) metastatic breast cancer (mBC) is highly aggressive and a major threat to human health. Despite the significant improvement in patients’ prognosis given the drug development efforts during t...
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Article
Open AccessAn efficient molecular genetic testing strategy for incontinentia pigmenti based on single-tube long fragment read sequencing
Incontinentia pigmenti (IP) is a rare X-linked dominant neuroectodermal dysplasia that primarily affects females. The only known causative gene is IKBKG, and the most common genetic cause is the recurrent IKBKG△4...
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Article
Targeting metabolism to enhance immunotherapy within tumor microenvironment
Cancer metabolic reprogramming has been considered an emerging hallmark in tumorigenesis and the antitumor immune response. Like cancer cells, immune cells within the tumor microenvironment or premetastatic ni...
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Article
Open AccessA dimension-aware gaining-sharing knowledge algorithm for distributed hybrid flowshop scheduling with resource-dependent processing time
The resource-assisted processing operation involves the coupling of multi-dimensional sub-problem, which poses a challenge in scheduling system. In this study, a dimension-aware gain-sharing knowledge algorith...
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Article
Open AccessMullerian adenosarcoma of the uterus with MASO: a case report of cervical adenosarcoma in a young female that never had sexual behavior
Cervical mullerian adenosarcoma is a rare uterine sarcoma, especially in young women. Its pathological features are low-grade malignant tumors with bidirectional differentiation, and the degree of malignancy i...
