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  1. No Access

    Article

    Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

    Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells (DCs) that, during hype...

    Jesse W. Williams, Konstantin Zaitsev, Ki-Wook Kim, Stoyan Ivanov… in Nature Immunology (2020)

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    Article

    Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

    Macrophages densely populate the arterial wall, yet their origin and homeostasis are poorly understood. Robbins and colleagues show that arterial macrophages arise from CX3CR1+ embryonic precursors and adult bone...

    Sherine Ensan, Angela Li, Rickvinder Besla, Norbert Degousee… in Nature Immunology (2016)

  3. No Access

    Article

    NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses

    CD8+ T cells primed in the absence of CD4+ T cell help fail to develop a robust memory cell response. Zloza et al. now report that these CD4-unhelped CD8+ T cells can be rescued by activating their cell surface r...

    Andrew Zloza, Frederick J Kohlhapp, Gretchen E Lyons, Jason M Schenkel… in Nature Medicine (2012)