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    Book

    Mathematical Modelling of Chromosome Replication and Replicative Stress

    Jens Karschau in Springer Theses (2015)

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    Chapter

    Summary and Conclusions

    Life is only possible because the genomic information in a cell’s chromosomes is copied from one generation to the next, by means of DNA replication.

    Jens Karschau in Mathematical Modelling of Chromosome Replication and Replicative Stress (2015)

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    Chapter

    Introduction

    To accomplish their numerous tasks cells must create and control an internal (spatial and temporal) order of processes by properly organising their resources. One of these processes—arguably the most crucial p...

    Jens Karschau in Mathematical Modelling of Chromosome Replication and Replicative Stress (2015)

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    Chapter

    Actively Replicating Domains Randomly Associate into Replication Factories

    In the previous chapter DNA was treated as a stiff, one-dimensional line. However within a cellular environment DNA diffuses and organises into structures on different scales as for instance being wrapped arou...

    Jens Karschau in Mathematical Modelling of Chromosome Replication and Replicative Stress (2015)

  5. No Access

    Chapter

    Optimal Origin Placement for Minimal Replication Time

    Eukaryotic genomes vary in their size and are much larger than their bacterial counterpart, e.g. that of Saccharomyces cerevisiae is \({\sim }\) ...

    Jens Karschau in Mathematical Modelling of Chromosome Replication and Replicative Stress (2015)