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Article
Open AccessDNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures
Modification of DNA resulting in 5-methylcytosine (5 mC) or 5-hydroxymethylcytosine (5hmC) has been shown to influence the local chromatin environment and affect transcription. Although recent advances in next...
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Article
Deep C diving: map** the low-abundance modifications of the DNA demethylation pathway
Two new studies imply that the reprogramming of 5-methylcytosine via TET- and TDG-family enzymes is both widespread throughout the genome and functionally significant.
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Article
Clinical Pharmacokinetics of the Newer Neuromuscular Blocking Drugs
The pharmacokinetics of 6 new neuromuscular blocking drugs are described. These are the aminosteroids pipecuronium bromide, rocuronium bromide and rapacuronium bromide (ORG-9487) and the benzylisoquinolinium d...
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Chapter and Conference Paper
The Pharmacokinetics of the Three Isomers of Mivacurium Chloride in Healthy, Renal and Hepatic Patients Given Short or Prolonged Infusions of the Drug
A solution of mivacurium chloride contains a mixture of three non-interchangeable stereoisomers; trans-trans (57%), cis-trans (37%) and cis-cis (6%)[1]. The trans-trans and cis-trans isomers are thought to have a...
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Chapter and Conference Paper
Benzylisoquinolinium Compounds in the Critically Ill Patient
Two main groups of neuromuscular blocking drugs are available for use in the Intensive Therapy Unit (ITU): the aminosteroids and the benzylisoquinolinium compounds. These drugs are occasionally used in such pa...
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Article
Renal haemodynamics with fentanyl
